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anti-Human CCR6 Antikörper:
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Human Monoclonal CCR6 Primary Antibody für CyTOF, FACS - ABIN4899109
Kapur, Mir, Clark Iii, Krishnamurti, Beech, Lillard, Singh: CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition. in British journal of cancer 2016
Show all 18 Pubmed References
Human Monoclonal CCR6 Primary Antibody für FACS - ABIN4895607
Spadaro, Caorsi, Ceruti, Varadhachary, Forni, Pericle, Giovarelli: Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008
Show all 16 Pubmed References
Human Monoclonal CCR6 Primary Antibody für FACS - ABIN4895542
Angkasekwinai, Sringkarin, Supasorn, Fungkrajai, Wang, Chayakulkeeree, Ngamskulrungroj, Angkasekwinai, Pattanapanyasat: Cryptococcus gattii infection dampens Th1 and Th17 responses by attenuating dendritic cell function and pulmonary chemokine expression in the immunocompetent hosts. in Infection and immunity 2014
Show all 11 Pubmed References
Human Monoclonal CCR6 Primary Antibody für FACS - ABIN4895605
Prendergast, Prado, Kang, Chen, Riddell, Luzzi, Goulder, Klenerman: HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cells. in AIDS 2010
Show all 10 Pubmed References
Human Monoclonal CCR6 Primary Antibody für FACS - ABIN2689057
Liao, Alderson, Su, Ullrich, Kreider, Farber: STRL22 is a receptor for the CC chemokine MIP-3alpha. in Biochemical and biophysical research communications 1997
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Human Monoclonal CCR6 Primary Antibody für FACS - ABIN2689058
Baba, Imai, Nishimura, Kakizaki, Takagi, Hieshima, Nomiyama, Yoshie: Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. in The Journal of biological chemistry 1997
Show all 6 Pubmed References
Mouse (Murine) Monoclonal CCR6 Primary Antibody für CyTOF, FACS - ABIN4899100
Röhrl, Yang, Oppenheim, Hehlgans: Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2. in Journal of immunology (Baltimore, Md. : 1950) 2010
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Mouse (Murine) Monoclonal CCR6 Primary Antibody für IHC, IHC (p) - ABIN4289187
Cecchinato, Bernasconi, Speck, Proietti, Sauermann, DAgostino, Danelon, Rezzonico Jost, Grassi, Raeli, Schöni-Affolter, Stahl-Hennig, Uguccioni: Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization. in Journal of immunology (Baltimore, Md. : 1950) 2016
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Human Polyclonal CCR6 Primary Antibody für IF (p), IHC (p) - ABIN731093
Kalyanasundaram Bhanumathy, Zhang, Xie, Xu, Tan, Xiang: Potent immunotherapy against well-established thymoma using adoptively transferred transgene IL-6-engineered dendritic cell-stimulated CD8(+) T-cells with prolonged survival and enhanced cytotoxicity. in The journal of gene medicine 2015
CCR6 facilitates tumor angiogenesis via the AKT (zeige AKT1 Antikörper)/NF-kappaB (zeige NFKB1 Antikörper)/VEGF (zeige VEGFA Antikörper) pathway in colorectal cancer
In conclusion, it seems that decreased expression of CXCR3 (zeige CXCR3 Antikörper) and higher expression of CCR6 were associated with HTLV-1 infection, what indicate that these alterations may favor virus dissemination but not disease manifestation.
Bin1 (zeige BIN1 Antikörper)-N-BAR domains assemble into scaffolds of low long-range order that form flexible membrane tubule in the sarcolemma
CCR6 defines memory B cell precursors in mouse and human germinal centers, revealing light-zone location and predominant low antigen affinity.
High expression of CCR6 is associated with cutaneous T-cell lymphoma.
CCR6(-) regulatory T cells blunt the restoration of gut (zeige GUSB Antikörper) Th17 cells along the CCR6-CCL20 (zeige CCL20 Antikörper) axis in treated HIV-1-infected patients.
results provide a potential explanation for involvement of the CCL20 (zeige CCL20 Antikörper)-CCR6 system in the trafficking of IL-17 (zeige IL17A Antikörper)-producing cells to degenerated IVD (zeige IVD Antikörper) tissues
The percentage of CXCR3 (zeige CXCR3 Antikörper)(+) CD4 (zeige CD4 Antikörper)(+) TEM (zeige CYLD Antikörper) cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA (zeige SELPLG Antikörper)(+) CD4 (zeige CD4 Antikörper)(+) TCM cells expressing CCR6(+) or CCR4 (zeige CCR4 Antikörper)(+)CXCR3 (zeige CXCR3 Antikörper)(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.
High CCR6 expression is associated with B-lymphoblastic lymphoma with inflammation.
CCR6 expression was higher in cells derived from node-positive cases and highest expression was in cells derived from metastatic cases of colon cancer.
Study identified protein and gene expression of chemokine receptor 6 in the hippocampus of Swiss mice with immunohistochemistry and RT-PCR, showed that CCR6 may be involved in normal neuronal activity in the hippocampus and play an important role in maintenance of the status epilepticus.
these data indicate that CCL20 (zeige CCL20 Antikörper)/CCR6 signaling may play an important role in regulating bone mass accrual, potentially by modulating osteoblast maturation, survival, and the recruitment of osteoblast-supporting cells.
CCR6 is upregulated rapidly within hours on the protein or mRNA level after activation in vitro.
These findings identify a crucial role for CCR6 in promoting LP-mononuclear phagocytes to associate with the intestinal epithelium in the steady state to perform multiple functions promoting gut (zeige GUSB Antikörper) immune homeostasis.
data suggest that gammadeltaT17 cells are completely dependent on CCR6 for homing to psoriasiform skin. Thus, CCR6 may constitute a novel target for a mechanistically distinct therapeutic approach to treating psoriasis.
Data (including data from studies using knockout mice or cells from knockout mice) suggest that HuR (zeige ELAVL1 Antikörper) post-transcriptionally regulates Ccr6 expression by binding to and stabilizing Ccr6 mRNA and by promoting Ccr6 translation in helper T-cells; knock-out of HuR (zeige ELAVL1 Antikörper) reduces Ccr6 expression on helper T-cells, impairs their migration to CNS, and prevents experimental autoimmune encephalomyelitis. (HuR (zeige ELAVL1 Antikörper) = Hu antigen R (zeige ELAVL1 Antikörper))
CCR6 deficiency affects hepatic inflammatory cell recruitment resulting in the promotion of hepatic inflammation and fibrosis.
in mice, activated B cells use the chemokine receptor CCR6 to access the subepithelial dome (SED) of Peyer's patches.
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.
chemokine (C-C motif) receptor 6
, C-C chemokine receptor type 6
, CC chemokine receptor 6
, c-C chemokine receptor type 6-like
, G protein-coupled receptor 29
, G-protein coupled receptor 29
, LARC receptor
, chemokine (C-C) receptor 6
, chemokine receptor-like 3
, seven-transmembrane receptor, lymphocyte, 22