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anti-Human CALCRL Antikörper:
anti-Mouse (Murine) CALCRL Antikörper:
anti-Rat (Rattus) CALCRL Antikörper:
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Human Polyclonal CALCRL Primary Antibody für IHC, IHC (p) - ABIN4287076 : Arimappamagan, Somasundaram, Thennarasu, Peddagangannagari, Srinivasan, Shailaja, Samuel, Patric, Shukla, Thota, Prasanna, Pandey, Balasubramaniam, Santosh, Chandramouli, Hegde, Kondaiah et al.: A fourteen gene GBM prognostic signature identifies association of immune response pathway and mesenchymal subtype with high risk group. ... in PLoS ONE 2013 (PubMed)
This study revealed for the first time an increase of mast-nerve association and CGRPR expression on mast cells during AR as well as nerve fibres containing receptors for mast cells.
Data suggest CGRP (zeige S100A12 Antikörper) receptor (CGRPR) ECL2 (extracellular loop 2 domain) enables interaction with N-terminal residues of CGRP (zeige S100A12 Antikörper); this provides evidence for dual involvement of ECL2 in two-domain binding model of CGRP (zeige S100A12 Antikörper)/CGRPR interaction; CGRPR is obligate heterodimer of CLR (zeige DCLK3 Antikörper)/RAMP1 (zeige RAMP1 Antikörper). (CGRP (zeige S100A12 Antikörper) = calcitonin gene-related peptide (zeige CALCA Antikörper); CLR (zeige DCLK3 Antikörper) = calcitonin receptor-like receptor; RAMP1 (zeige RAMP1 Antikörper) = receptor [calcitonin (zeige CALCA Antikörper)] activity modifying protein 1)
Mouse and human heart valves expressed mRNAs for the CRL (zeige IL31RA Antikörper) ligands adrenomedullin (zeige ADM Antikörper) (AM), adrenomedullin-2 (AM-2 (zeige ADM2 Antikörper)) and calcitonin gene-related peptide (CGRP (zeige CALCA Antikörper)) and for their receptor components, i.e., CRL (zeige IL31RA Antikörper) and receptor-activity-modifying proteins 1-3.
interaction of RAMP2 (zeige RAMP2 Antikörper) or RAMP3 (zeige RAMP3 Antikörper) with CLR (zeige DCLK3 Antikörper) induces conformational variation in the juxtamembrane region, yielding distinct binding pockets, probably via an allosteric mechanism.
STC1 (zeige STC1 Antikörper) interferes with CALCRL signaling during osteoblastogenesis via adenylate cyclase inhibition.
Data suggest that ligand binding of a G protein-coupled receptor (GPCR (zeige TAS1R3 Antikörper)) may inform drug development targeting calcitonin receptor-like receptor (CLR):receptor activity-modifying proteins RAMP1 (zeige RAMP1 Antikörper)/2 complexes.
the AM system is widely expressed in human thymus from newborns; both AM1 receptor components CLR (zeige DCLK3 Antikörper) and RAMP2 (zeige RAMP2 Antikörper), but not RAMP3 (zeige RAMP3 Antikörper), are not associated with the plasma membrane of TECs and thymocytes but are located intracellularly, notably in the nucleus
Two CALCRL variants were associated with risk for gestational diabetes.
Data suggest isoforms of RAMP (receptor activity-modifying protein) modulate accessibility of peptides to residues situated on CALCRL N-terminal domain; RAMP3 (zeige RAMP3 Antikörper)/RAMP2 (zeige RAMP2 Antikörper)/RAMP1 (zeige RAMP1 Antikörper) appear to alter accessibility of specific residues at CALCRL-RAMP interface.
CRLR expression is upregulated in the fetal lung with increasing gestational age.
the cardiovascular response of Ramp1 (zeige RAMP1 Antikörper)(-/-), Ramp2 (zeige RAMP2 Antikörper)(+/-), Ramp3 (zeige RAMP3 Antikörper)(-/-), Ramp1 (zeige RAMP1 Antikörper)(-/-)/Ramp3 (zeige RAMP3 Antikörper)(-/-) double-knockout (dKO), and Calcrl(+/-) mice to AM and CGRP (zeige CALCA Antikörper) were compared to wildtype mice.These results suggest that the hypotensive effect of AM is primarily mediated through the CLR (zeige CALCR Antikörper)/RAMP1 (zeige RAMP1 Antikörper) heterodimer, but that AM signaling via CLR (zeige CALCR Antikörper)/RAMP2 (zeige RAMP2 Antikörper) and CLR (zeige CALCR Antikörper)/RAMP3 (zeige RAMP3 Antikörper) also contributes to some hypotensive action.
Mouse and human heart valves expressed mRNAs for the CRL (zeige BNC2 Antikörper) ligands adrenomedullin (zeige ADM Antikörper) (AM), adrenomedullin-2 (AM-2 (zeige ADM2 Antikörper)) and calcitonin gene-related peptide (CGRP (zeige CALCA Antikörper)) and for their receptor components, i.e., CRL (zeige BNC2 Antikörper) and receptor-activity-modifying proteins 1-3.
these data indicate that the structural integrity of caveolae plays an important role in regulating subcellular distribution of CLR (zeige CALCR Antikörper).
Calcrl deficiency results in multi-organ lymphangiectasia in adult mice.
Data show that mechanical ventilation reduced the expression of receptor activity-modifying protein RAMP3 (zeige RAMP3 Antikörper), but not of intermedin (IMD (zeige ADM2 Antikörper)), calcitonin receptor-like receptor (CRLR), and RAMP1 (zeige RAMP1 Antikörper) and RAMP2 (zeige RAMP2 Antikörper).
role in cell surface expression of CRLR/RAMP heterodimeric receptors
The Calcrl gene targeted mice provide the first in vivo genetic evidence that Calcitonin receptor (zeige CALCR Antikörper) functions as an Adrenomedullin receptor (zeige GPR182 Antikörper) during embryonic development.
loss of calcrl in endothelial cells confirmed an essential role for AM signaling in vascular development.
CTR (zeige CALCR Antikörper) is not only down regulated by signaling through the CTR (zeige CALCR Antikörper) but also by the peptides signaling through calcitonin receptor-like receptor, and receptor activity modifying proteins
Data suggest that ADM (adrenomedullin (zeige ADM Antikörper)) increases oviductal fluid secretion via chloride secretion by calcium and cAMP signal pathways (not nitric oxide signal pathway) via CGRPR (calcitonin gene-related peptide (zeige CALCA Antikörper) receptor; not adrenomedullin receptor (zeige GPR182 Antikörper)).
Data indicate that adrenomedullin (zeige ADM Antikörper) mRNA and protein signal were only found in trophoblast binucleate cells (BNCs), whereas those of CRLR, RAMP2 (zeige RAMP2 Antikörper) and RAMP3 (zeige RAMP3 Antikörper) were detected in cotyledonary villous and caruncular epithelial cells.
Receptor for calcitonin-gene-related peptide (CGRP) (By similarity). Receptor specificity may be modulated by accessory proteins. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).
calcitonin receptor-like , calcitonin gene-related peptide type 1 receptor-like , CGRP type 1 receptor , Calcitonin receptor-like receptor , calcitonin gene-related peptide type 1 receptor , calcitonin receptor-like receptor