Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Wählen Sie die Spezies und Applikation aus
anti-Human APLP1 Antikörper:
anti-Mouse (Murine) APLP1 Antikörper:
anti-Rat (Rattus) APLP1 Antikörper:
Sie gelangen zu unserer vorgefilterten Suche.
These data reveal a conserved mechanism for the binding of APP (zeige APP Antikörper)-family proteins to HS and imply a specific regulatory role of HS modifications in the biology of APP (zeige APP Antikörper) and APP-like (zeige APP Antikörper) proteins.
APLP1 and APLP2 (zeige APLP2 Antikörper), behave similarly to APP (zeige APP Antikörper) in that they both associate with assembled NMDA receptors in the endoplasmic reticulum
CSF (zeige CSF2 Antikörper) levels of 3 endogenous peptides derived from APLP1 (APL1beta25, APL1beta27 and APL1beta28) were decreased in Down syndrome.
APLP1 has a regulatory role in the nuclear translocation of APP (zeige APP Antikörper) family intracellular domains due to the sequestration of Fe65 (zeige APBB1 Antikörper).
[review] APP (zeige APP Antikörper) and its mammalian homologs, amyloid precursor-like proteins APLP1 and APLP2 (zeige APLP2 Antikörper), participate under physiological conditions via trans-cellular dimerization in synaptogenesis.
APLP1 binds the II-III loop of the Ca(v)2.3 calcium channel and that this binding promotes internalization of the channel.
Both APLP1 and APLP2 (zeige APLP2 Antikörper), form transcriptionally active triple protein complexes with Mint3 (zeige APBA3 Antikörper) and transcriptional co-activators Taz (zeige TAZ Antikörper) andYap.
Human cerebrospinal fluid contains three APLP1-derived Abeta (zeige APP Antikörper)-like peptides that are generated by beta- and gamma-cleavages at a concentration of approximately 4.5 nM.
APLP1 and APLP2 (zeige APLP2 Antikörper) are processed by the gamma-secretase in a Presenilin 1 (zeige PSEN1 Antikörper)-dependent manner and the extreme carboxyl-terminal fragments produced by this processing (APP-like (zeige APP Antikörper) Intracellular Domain) are able to enhance Fe65 (zeige APBB1 Antikörper)-dependent gene activation
APLP1 does not undergo the same type of regulated processing as APP (zeige APP Antikörper) and APLP2 (zeige APLP2 Antikörper).
APLP1 exhibits synaptogenic activity, involving trans-synaptic dimerization. APLP1 knock-out mice show impaired basal transmission and a reduced mEPSC frequency.
Results suggest that APLP1 deficiency on its own does not lead to defects in synaptic plasticity, but affects synaptic transmission and network inhibition in the dentate gyrus
[review] A role of APP (zeige APP Antikörper) and its two closely related homologues APLP1 and APLP2 (zeige APLP2 Antikörper) has been determined in various aspects of nervous system development and function, in particular, for synapse formation and function.
findings demonstrated that NB-2 (zeige CNTN5 Antikörper) interacts with APLP and that both NB-2 (zeige CNTN5 Antikörper) and APLP1 are localized at presynaptic sites, suggesting that NB-2 (zeige CNTN5 Antikörper) associates with APLP1 in a cis (zeige CISH Antikörper) manner on the presynaptic membrane
Crystal structure of the E2 domain of amyloid precursor protein-like (zeige APP Antikörper) protein 1 in complex with sucrose octasulfate.
The 5' UTR (zeige UTS2R Antikörper) of the Aplp1 gene lacks any type of CAGA (zeige S100A8 Antikörper) box. This may explain its inability to form amyloid plaques.
Cytoplasmic polyadenylation element (CPE (zeige CPE Antikörper)) binding factor binds the small intracellular domain (ICD) of APLP1.
The results demonstrated that cell viability and neurite outgrowth of N2a cells undergoing knockdown of Aplp1 were significantly reduced, compared with N2a cells undergoing knockdown of either App (zeige APP Antikörper) or Aplp2 (zeige APLP2 Antikörper).
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
amyloid-like protein 1
, amyloid beta (A4) precursor-like protein 1
, amyloid-like protein 1-like
, amyloid precursor-like protein 1