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anti-Mouse (Murine) AKAP12 Antikörper:
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Human Monoclonal AKAP12 Primary Antibody für ELISA, WB - ABIN564142
Tan, Tan, Lin, Lim, Hew, Chung: Quantitative and temporal proteome analysis of butyrate-treated colorectal cancer cells. in Molecular & cellular proteomics : MCP 2008
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Human Polyclonal AKAP12 Primary Antibody für IP, WB - ABIN261126
Mardin, Petrov, Enns, Senninger, Haier, Mees: SERPINB5 and AKAP12 - expression and promoter methylation of metastasis suppressor genes in pancreatic ductal adenocarcinoma. in BMC cancer 2010
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Cow (Bovine) Polyclonal AKAP12 Primary Antibody für IHC (fro), IP - ABIN4369744
Nelson, Moissoglu, Vargas, Klotman, Gelman: Involvement of the protein kinase C substrate, SSeCKS, in the actin-based stellate morphology of mesangial cells. in Journal of cell science 1999
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Human Polyclonal AKAP12 Primary Antibody für ELISA, WB - ABIN4278915
Nauert, Klauck, Langeberg, Scott: Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein. in Current biology : CB 1997
Human Polyclonal AKAP12 Primary Antibody für ICC, IF - ABIN4278917
Bateman, Jaworski, Ao, Wang, Litzi, Dubil, Marcus, Conrads, Teng, Hood, Phippen, Vasicek, McGuire, Paz, Sidransky, Hamilton, Maxwell, Darcy, Conrads: Elevated AKAP12 in paclitaxel-resistant serous ovarian cancer cells is prognostic and predictive of poor survival in patients. in Journal of proteome research 2015
Loss of akap12 function causes severe defects in locomotor activity in zebrafish embryos.
Zebrafish embryos depleted of akap12 (akap12 morphants) exhibited severe hemorrhages.
Gravin is required for the conversion of mesodermal cells from a highly migratory behavior to the medio-laterally intercalative behavior required for body axis extension.
These results provide an important step forward in understanding the mechanism of Gravin function in cell shape regulation and provide valuable insight into how Gravin acts as a cytoskeletal regulator.
suggest that AKAP12 signaling in pericytes may be required for oligodendrocyte precursor cells-to-oligodendrocyte renewal to maintain the white matter homeostasis in adult brain
fibrosis induced by Ang II may be alleviated by AKAP12 expression through inactivation of the TGF-beta1 pathway.
gravin is an important component of cardiac contraction
The enrichment of activated Cdc42 in SSeCKS-null leading edge filopodia correlated with recruitment of the Cdc42-specific guanine nucleotide exchange factor, Frabin.
AKAP12 scaffolding protein mediates meningeal reconstruction after central nervous system injury
Results suggest that AKAP12-positive cells in the fibrotic scar may restrict excessive inflammation, demonstrating mechanisms that could underlie the beneficial actions of the fibrotic scar in the new tissue formation stage during the CNS repair process.
Disruption of gravin's scaffold mediated signaling is able to increase baseline cardiac function as well as to augment contractility in response to acute beta-AR stimulation.
We conclude that gravin compartmentalizes a significant pool of PKA that regulates learning-induced beta2-adrenergic receptor signaling and ERK activation in the hippocampus
Our study implicates a role for SSeCKS in preventing of skin cancer progression possibly through negatively regulating FAK expression.
controls the localization and activity of cyclin D1 in parietal epithelial cells and influences proliferative injury in the glomerulus
PKC-mediated remodeling of the actin cytoskeleton is likely regulated by the ability of SSeCKS to control PKC signaling and activity through a direct scaffolding function
Akap12 controls Rb-mediated cell aging and oncogenic progression by directly scaffolding and attenuating PKCalpha/delta.
SERPINB5 and AKAP12 may have a role in increased metastasis in pancreatic ductal adenocarcinoma
induced in vascular endothelial cells by bacterial lipopolysaccharide
SSeCKS has a restricted distribution within the nervous system and that expression of this protein may reflect the specific signaling requirements of a distinct population of nociceptive sensory neurons.
Phosphorylation of SSeCKS by mitogenically activated kinases decreases intrinsic cell scaffolding activities and suggests that SSeCKS regulatory functions are lost in the late G1 phase.
a role for SSeCKS in mitogen-induced cytoskeletal reorganization.
SSeCKS expression in endothelial cells and reticular cells is a functional index of the reticulo-endothelial system
alternately targeted anchoring protein isoforms provide a mechanism for genetic control of signaling specificity by AKAP12
AKAP12alpha belongs to a novel class of atypical SRF-dependent target genes
Disruption of a Gravin-PLK1 interface leads to inappropriate PLK1 activity contributing to chromosome segregation errors, formation of micronuclei, and subsequent DNA damage.
the findings in this study suggest that AKAP12 is a potential metastasis suppressor in breast cancer.
Low AKAP12 expression is associated with high-grade meningiomas.
these findings indicate that AKAP12 may be a potential prognostic predictor and therapeutic target for the treatment of colorectal cancer in combination with HDAC3
There is a positive association between the expression of AKAP12 and Semaphorin 3F in prostate cancer, suggesting that the activation of Semaphorin 3F by AKAP12 may be involved in prostate cancer progression and metastasis.
A critical role for AKAP12 as an UV-inducible scaffold for PKA-mediated ATR phosphorylation.
the AKAP12a promoter shows high DNA methylation levels in juvenile myelomonocytic leukemia, which go along with reduced AKAP12a mRNA expression levels
MiR-103 regulates hepatocellular carcinoma growth by targeting AKAP12
results suggest that the association between the 6q25.1 locus and breast cancer risk may be mediated through single nucleotide polymorphisms that regulate expressions of the AKAP12 gene.
The authors propose that Gravin-mediated recruitment of Aurora A and Plk1 to the mother (oldest) spindle pole contributes to the fidelity of symmetric cell division.
The SSeCKS, a major Lipopolysaccharide (LPS) response protein, has been involved in regulating astrocyte activation via production of proinflammatory factor in CNS inflammation.
Elevated expression of AKAP12 is characteristic of paclitaxel-resistant high-grade serous ovarian cancer cells, and a prognostic and predictive marker for poor overall survival in SOC patients.
Cigarette smoke-induced changes in AKAP5 and AKAP12 in patients with COPD may affect efficacy of pharmacotherapy.
PKA compartmentalization via AKAP220 and AKAP12 contributes to endothelial barrier regulation.
This study showed that AKAP12,CAMK2D and a molecular pathway(cyclic amp)association to outcome of depressive during citalopram treatment.
AKAP12 variant 2 hypoxic induction shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells
AKAP12 expression was positive in 82.2% of tumors in a cohort with colorectal adenocarcinoma. AKAP12 expression was unrelated to p53 or Bcl-2 expression.
Receptor-mediated Ca2+ and PKC signaling triggers the loss of cortical PKA compartmentalization through the redistribution of gravin.
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
A kinase (PRKA) anchor protein (gravin) 12
, A-kinase anchor protein 12
, A kinase (PRKA) anchor protein 12
, A kinase anchor protein 12
, A-kinase anchor protein 12-like
, a-kinase anchor protein 12-like
, germ cell lineage protein gercelin
, src-suppressed C kinase substrate
, testis specific gene A12
, v-src suppressed transcript 5
, SSeCKS, Gravin, AKAP250
, A-kinase anchor protein, 250kDa
, AKAP 250
, Src-Suppressed C Kinase Substrate
, kinase scaffold protein gravin
, myasthenia gravis autoantigen gravin