CACNA1H Proteine (CACNA1H)

Human Calcium Channel, Voltage-Dependent, T Type, alpha 1H Subunit (CACNA1H) Interaktionspartner

1. In colonic biopsies, the Cav3.2 mRNA level was significantly higher in the irritable bowel syndrome group compared to controls.

2. human Cav3.1, Cav3.2, and Cav3.3 T-type channels specifically associate with CaM at helix 2 of the gating brake in the I-II linker of the channels.

3. Here we show that T-type channels Cav3.1 (zeige CACNA1G Proteine) and Cav3.2 are present in the lung and PASMCs from iPAH patients and control subjects. The blockade of T-type channels by the specific blocker, TTA-A2, prevents cell cycle progression and PASMCs growth

4. Our data establish Stac1 (zeige STAC Proteine) as an important modulator of T-type channel expression and provide new insights into the molecular mechanisms underlying the trafficking of T-type channels to the plasma membrane.

5. CACNA1H variant is associated with differential antiepileptic drug response in childhood absence epilepsy.

6. There is a direct link between CACNA1H(M1549V) mutation and an increased aldosterone production. This suggests that calcium channel blockers may be beneficial in the treatment of a subset of patients with primary aldosteronism.

7. CACNA1H might be a susceptibility gene predisposing to PA with different phenotypic presentations, opening new perspectives for genetic diagnosis and management of patients with PA.

8. heterozygous mutations identified in a pediatric patient with chronic pain and absence seizures result in loss of channel function, with significantly smaller current densities across a wide range of voltages when co-expressed in tsA (zeige PRDX2 Proteine)-201 cells.

9. CaV3.1 (zeige CACNA1G Proteine), CaV3.2 and CaV3.3 (zeige CACNA1I Proteine) channels, are best recognized for their negative voltage of activation and inactivation thresholds that allow them to operate near the resting membrane potential of neurons.

10. Study revealed no association between the 15 tagSNPs of CACNA1A (zeige CACNA1A Proteine), 1C, and 1H and antiepileptic drug efficacy in the Chinese Han epileptic population; the TAGAA haplotype of CACNA1A (zeige CACNA1A Proteine) may be a risk factor for drug resistance

Mouse (Murine) Calcium Channel, Voltage-Dependent, T Type, alpha 1H Subunit (CACNA1H) Interaktionspartner

1. Findings provided morphological evidence that T-type Cav3.2 channel, at least partially, mediates the pain facilitation of insulin-like growth factor-1/insulin-like growth factor-1 (zeige IGF1 Proteine) receptor (zeige IGF1R Proteine) signaling in chronic inflammatory pain condition.

2. This study found that expressions of Cav3.2 and IGF-1R (zeige IGF1R Proteine), and their colocalization were not increased in DRGs of mice following axotomy. In addition, Cav3.2 or IGF-1R (zeige IGF1R Proteine) subpopulation neurons did not acquire significant switch in expression phenotype after sciatic nerve axotomy.

3. Sensitization was relieved by pharmacological block of TRPV1 (zeige TRPV1 Proteine) afferents, but not of myelinated neurons. In spinal cord slice recordings, we could optogenetically trigger an activity-dependent potentiation of presynaptic neurotransmission in the spinal dorsal horn that relied on Cav3.2 channel activity. This neuronal-activity-induced USP5 (zeige USP5 Proteine) upregulation may underlie a protective, transient sensitization of the pain pathway.

4. The important roles of the CaV (zeige CA5A Proteine) 3.2 T-type calcium channels in myogenic tone.

5. findings show that 2 Amyotrophic lateral sclerosis (ALS)-associated missense mutations produce alterations on the channel activity, consistent with a loss of channel function; findings implicate CACNA1H as a susceptibility gene in one form of ALS

6. findings suggest that chronic intermittent hypoxia leads to an augmented calcium influx via reactive oxygen species -dependent facilitation of CaV3.2 protein trafficking to the plasma membrane.

7. these data show that CaV3.2 T-type channels have prev8iously unrecognized roles in supporting the meiotic-maturation-associated increase in ER Ca(2 (zeige CA2 Proteine)+) stores and mediating Ca(2 (zeige CA2 Proteine)+) influx required for the activation of development.

8. MTF1 (zeige MTF1 Proteine) mediates the increase of CaV3.2 mRNA and a rise in intracellular Zn(2+) which is associated with status epilepticus.

9. both suramin and gossypetin produced dose-dependent and long-lasting mechanical anti-hyperalgesia that was abolished or greatly attenuated in Cav3.2 null mice

10. Data show increased expression of T-type Ca(2 (zeige CA2 Proteine)+) current and association of protein kinase C alpha (PKCalpha (zeige PKCa Proteine)) with caveolin-3 (Cav-3 (zeige CAV3 Proteine))was disrupted in the hypertrophic ventricular myocyte.