Propidium Iodide

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Enzyme Activity Assay (EAA), Functional Studies (Func)
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Chemical Name 3,8-Diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium diiodide, PI
Formel C₂₇H₃₄I₂N₄
Permeabilität Not-permeable
Molekulargewicht 668.39 g/mol
CAS-Nummer 25535-16-4

Propidium Iodide (PI) binds to double-stranded DNA, but it can only cross the plasma membrane of nonviable cells. When viewed using a fluorescence microscope with a rhodamine filter, cells that have lost membrane integrity will show red PI staining throughout the nuclei. For analysis by flow cytometry, the PI staining can be monitored in FL2 channel.

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Handhabung Protect from light and moisture
Lagerung 4 °C
Haltbarkeit 12 months
Bilder des Herstellers
 image for Propidium Iodide (ABIN412371) Propidium Iodide
Produkt verwendet in: Yamamoto, Obana, Yee, Asai, Nomura, Nakamura: "SP10 infectivity is aborted after bacteriophage SP10 infection induces nonA transcription on the prophage SPβ region of the Bacillus subtilis genome." in: Journal of bacteriology, Vol. 196, Issue 3, pp. 693-706, 2014 (PubMed).

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Kar, Quesada: "A numerical simulation approach to studying anterior cruciate ligament strains and internal forces among young recreational women performing valgus inducing stop-jump activities." in: Annals of biomedical engineering, Vol. 40, Issue 8, pp. 1679-91, 2012 (PubMed).

Tanaka, Jin, Lee, Zhang, Kim, Stolz, Ryter, Choi: "Hyperoxia-induced LC3B interacts with the Fas apoptotic pathway in epithelial cell death." in: American journal of respiratory cell and molecular biology, Vol. 46, Issue 4, pp. 507-14, 2012 (PubMed).

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Mao, Hou, Cao, Wang, Li, Chen, Fei, Hurren, Gronda, Wu, Trudel, Schimmer: "The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: in vitro and in silico evidence." in: Molecular pharmacology, Vol. 79, Issue 4, pp. 672-80, 2011 (PubMed).

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Sharmeen, Skrtic, Sukhai, Hurren, Gronda, Wang, Fonseca, Sun, Wood, Ward, Minden, Batey, Datti, Wrana, Kelley, Schimmer: "The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells." in: Blood, Vol. 116, Issue 18, pp. 3593-603, 2010 (PubMed).

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