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While much is known about how C/EBPalpha orchestrates granulopoiesis, our understanding of molecular transformation events, the role(s) of cooperating mutations and clonal evolution during C/EBPalpha deregulation in leukemia remains elusive. In this review, we will summarize the latest research addressing these topics with special emphasis on CEBPA mutations
miR-182 is a strong regulator of C/EBPalpha. There is a regulatory loop between C/ (zeige MLXIP Proteine)EBPalpha and miR-182. While C/EBPalpha blocks miR-182 expression by direct promoter binding during myeloid differentiation, enforced expression of miR-182 reduces C/EBPalpha protein level and impairs granulopoiesis in vitro and in vivo.
CHOP (zeige DDIT3 Proteine) negatively regulates Polo-like kinase 2 (zeige PLK2 Proteine) expression via recruiting C/EBPalpha to the upstream-promoter in human osteosarcoma cell line during ER stress
C/EBPalpha overexpression suppressed the epithelial-mesenchymal transition (EMT (zeige ITK Proteine)) that was characterized by a gain of epithelial and loss of mesenchymal markers. Further study showed that C/EBPalpha suppressed the transcription of beta-catenin (zeige CTNNB1 Proteine) and downregulated the levels of its downstream targets.
Binding of C/EBPalpha was associated with increased deacetylation near the transcription start site (TSS) of the PLK1 promoter.
a MEF2C and CEBPA correlation in CML disease progression
CEBPA gene expression is significantly associated with long-term changes in Blood Pressure, providing a link between gene expression and Blood Pressure.
We provide evidence that CCAAT/enhancer-binding protein alpha directly binds the miR (zeige MLXIP Proteine)-203 gene within its hairpin region and thereby induces miR (zeige MLXIP Proteine)-203 transcription
High CEBP expression is associated with glioblastomas.
identified high frequencies of mutations in CEBPA (32.7%), GATA2 (zeige GATA2 Proteine) (22.4%), NPM1 (zeige NPM1 Proteine) (15.5%), SETBP1 (zeige SETBP1 Proteine) (12.1%) and U2AF1 (zeige U2AF1 Proteine)
The Bach2 (zeige BACH2 Proteine)-C/EBPbeta (zeige CEBPB Proteine) gene regulatory network pathway tunes multipotent progenitor commitment to myeloid and lymphoid lineages both under normal conditions and after infection.
Data demonstrate the importance of a controlled balance between C/EBPalpha and miR (zeige MLXIP Proteine)-182 for the maintenance of healthy granulopoiesis.
Functional characterization of C/EBPa and C/EBPb (zeige CEBPB Proteine) proteomes suggests they can regulate novel pathways.
results indicate that JMJD2B regulates PPARgamma (zeige PPARG Proteine) and C/EBPalpha during adipogenesis
A single +42-kb enhancer is essential for CEBPA expression in myeloid cells only.
these data indicate that CycC (zeige CCNC Proteine) activates adipogenesis in part by stimulating the transcriptional activity of C/EBPalpha.
Taken together, these findings demonstrate that artesunate inhibits adipogenesis in 3T3-L1 preadipoytes through the reduced expression and/or phosphorylation levels of C/EBP-alpha, PPAR-gamma (zeige PPARG Proteine), FAS (zeige FAS Proteine), perilipin A (zeige PLIN1 Proteine), and STAT-3 (zeige STAT3 Proteine).
we show that SIX1 (zeige SIX1 Proteine) binds to adipogenic and brown marker genes and interacts with C/EBPa, C/EBPb (zeige CEBPB Proteine) and EBF2 (zeige EBF2 Proteine), suggesting their functional cooperation during adipogenesis.
these results indicate that C/EBPalpha functions throughout osteoclastogenesis as well as in Osteoclast function. This study provides additional understanding of the roles of C/EBPalpha in Osteoclast biology.
the DNA sequences to which EVI1 (zeige MECOM Proteine) binds at +35 and +37 kb and show that mutation of one of these releases Cebpa from EVI1 (zeige MECOM Proteine)-induced suppression.
C/ebpalpha plays a role in liver growth regulation via the p53 (zeige TP53 Proteine) pathway.
Dnmt1 (zeige DNMT1 Proteine) is required for hematopoietic stem and progenitor cells maintenance via cebpa regulation during definitive hematopoiesis in zebrafish
Data suggest that upregulation of 10-formyltetrahydrofolate dehydrogenase (FDH (zeige ALDH1L1 Proteine)) involving CEBPalpha helps relieve embryonic oxidative stress induced (zeige SQSTM1 Proteine) by ethanol exposure.
Bmi1 (zeige BMI1 Proteine) acts immediately downstream of CCAAT enhancer binding protein-alpha to regulate the survival and self-renewal of hematopoietic stem cells and contribute to the erythropoietic dysplasia.
Results provide first evidence that sumoylation of Cebp-alpha (via SUMO1 (zeige SUMO1 Proteine), SUMO2 (zeige SUMO2 Proteine), and SUMO3 (zeige SUMO3 Proteine)) might contribute to cell fate decision of myelo-erythroid progenitor cells in intermediate cell mass during primitive [extramedullary] hematopoiesis.
An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 (zeige CTNNA1 Proteine) axis controls myeloid development and transformation.
a C/EBP recognition sequence in the proximal promoter region of C/EBPalpha is essential for IL-6 (zeige IL6 Proteine)-mediated repression
These results suggest that the CEBPA gene is a strong candidate gene that affects carcass traits in Qinchuan cattle.
Expressions of C-EBPalpha and myostatin (zeige MSTN Proteine) in muscles were higher in the concentrate-fed group than in the grass hay (zeige GTF2H5 Proteine)-fed group.
C/EBPalpha is an essential regulatory factor for perilipin5 transcription and suggest that fasting stimulates perilipin5 transcription through influencing C/EBPalpha expression.
The differential expression of specific CEBPA/B isoforms observed in maturing follicles and CL may contribute to changes in follicular cell differentiation and increasing steroidogenic capacity.
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.
CCAAT/enhancer-binding protein alpha
, C/EBP alpha
, CAAT/enhancer-binding protein DNA-binding protein
, CAAT/enhancer-binding protein, DNA-binding protein
, CCAAT/enhancer binding protein, alpha
, c/EBP alpha
, CCAAT/enhancer binding protein alpha