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The earliest steps of adult hepatocellular carcinoma and aggressive pediatric liver cancer have identical features that include conversion of the tumor suppressor C/EBPalpha into an oncogenic isoform, which further creates preneoplastic foci where hepatocytes dedifferentiate into cancer cells, giving rise to liver cancer
Data suggest that up-regulation of NPY (zeige NPY Proteine) inhibits proliferation of adipose-derived stem cells while promoting adipogenesis and up-regulating expression of white adipocyte biomarkers PPARG (zeige PPARG Proteine), CEBPA, CIDEC (zeige CIDEC Proteine), and RIP140 (zeige NRIP1 Proteine). (NPY (zeige NPY Proteine) = neuropeptide Y (zeige NPY Proteine); PPARG (zeige PPARG Proteine) = peroxisome proliferator activated receptor gamma (zeige PPARG Proteine); CIDEC (zeige CIDEC Proteine) = cell death-inducing DFFA-like effector C (zeige CIDEC Proteine); RIP140 (zeige NRIP1 Proteine) = nuclear receptor interacting protein 1 (zeige NRIP1 Proteine))
Study identified for the first time that HNF4alpha (zeige HNF4A Proteine) and C/EBPalpha are important transcriptional regulators for FBP1 (zeige FBP1 Proteine) expression in human hepatoma HepG2 cells.
The presence of biallelic CEBPA mutations is a favourable prognostic feature in acute myeloid leukaemia.
C/EBP-alpha mediates anti-inflammatory effects in podocytes
proteogenomics profiling study reveals that an activation of C/EBPalpha, along with the upregulation of its lipogenesis targets, accounts for lipid storage and acts as a hallmark of ARVC ( Arrhythmogenic right ventricular cardiomyopathy)
Taken together, the authors propose that the miR (zeige MLXIP Proteine)-939-Jmjd3 axis perturbs the accessibility of hepatitis B virus enhancer II/core promoter (En II) promoter to essential nuclear factors (C/EBPalpha and SWI (zeige SMARCA1 Proteine)/SNF (zeige SNRPA Proteine) complex) therefore leading to compromised viral RNA synthesis and hence restricted viral multiplication.
EBPA and RUNX1 (zeige RUNX1 Proteine) are expressed at higher levels in patients with acute myeloid leukemia (zeige BCL11A Proteine) in comparison to healthy subjects
Integration of WGS-based fine-mapping and complementary epigenomic datasets provided evidence for causal mechanisms at several loci, including at a previously undiscovered basophil count-associated locus near the master hematopoietic transcription factor CEBPA The fine-mapped variant at this basophil count association near CEBPA overlapped an enhancer active in common myeloid progenitors and influenced its activity.
in our study on a large cohort of CEBPAmut AML (zeige RUNX1 Proteine) patients, we found a high coincidence of GATA2mut, in particular within the subgroup of patients with CEBPAbi mutations
The earliest steps of adult hepatocellular arcinoma and aggressive pediatric liver cancer have identical features that include conversion of the tumor suppressor C/EBPalpha into an oncogenic isoform, which further creates preneoplastic foci where hepatocytes dedifferentiate into cancer cells, giving rise to liver cancer
under nutrient-limiting conditions that stimulate ATF4 (zeige ATF4 Proteine) activity, TRIB3 (zeige TRIB3 Proteine) is implicated in the regulation of metabolic adaptation by restraining the transcription of Fgf21 (zeige FGF21 Proteine).
the extracts dramatically attenuated the levels of adipogenic transcriptional factors, including CCAAT enhancer-binding protein alpha (C/EBPa), CCAAT enhancer-binding protein beta (C/EBPb (zeige CEBPB Proteine)), and gamma receptors by peroxisome proliferators (PPARg (zeige PPARG Proteine)), during adipogenesis
shown that ectopic miR (zeige MLXIP Proteine)-155 expression and loss of C/EBPA expression in myeloid progenitor cells cooperate in transformation of HSPCs toward AML (zeige RUNX1 Proteine) in the absence of FLT3 (zeige FLT3 Proteine)-ITD
The Bach2 (zeige BACH2 Proteine)-C/EBPbeta (zeige CEBPB Proteine) gene regulatory network pathway tunes multipotent progenitor commitment to myeloid and lymphoid lineages both under normal conditions and after infection.
Data demonstrate the importance of a controlled balance between C/EBPalpha and miR (zeige MLXIP Proteine)-182 for the maintenance of healthy granulopoiesis.
Functional characterization of C/EBPa and C/EBPb (zeige CEBPB Proteine) proteomes suggests they can regulate novel pathways.
results indicate that JMJD2B regulates PPARgamma (zeige PPARG Proteine) and C/EBPalpha during adipogenesis
A single +42-kb enhancer is essential for CEBPA expression in myeloid cells only.
C/ebpalpha plays a role in liver growth regulation via the p53 (zeige TP53 Proteine) pathway.
Dnmt1 (zeige DNMT1 Proteine) is required for hematopoietic stem and progenitor cells maintenance via cebpa regulation during definitive hematopoiesis in zebrafish
Data suggest that upregulation of 10-formyltetrahydrofolate dehydrogenase (FDH (zeige ALDH1L1 Proteine)) involving CEBPalpha helps relieve embryonic oxidative stress induced (zeige SQSTM1 Proteine) by ethanol exposure.
Bmi1 (zeige BMI1 Proteine) acts immediately downstream of CCAAT enhancer binding protein-alpha to regulate the survival and self-renewal of hematopoietic stem cells and contribute to the erythropoietic dysplasia.
Results provide first evidence that sumoylation of Cebp-alpha (via SUMO1 (zeige SUMO1 Proteine), SUMO2 (zeige SUMO2 Proteine), and SUMO3 (zeige SUMO3 Proteine)) might contribute to cell fate decision of myelo-erythroid progenitor cells in intermediate cell mass during primitive [extramedullary] hematopoiesis.
An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 (zeige CTNNA1 Proteine) axis controls myeloid development and transformation.
a C/EBP recognition sequence in the proximal promoter region of C/EBPalpha is essential for IL-6 (zeige IL6 Proteine)-mediated repression
These results suggest that the CEBPA gene is a strong candidate gene that affects carcass traits in Qinchuan cattle.
Expressions of C-EBPalpha and myostatin (zeige MSTN Proteine) in muscles were higher in the concentrate-fed group than in the grass hay (zeige GTF2H5 Proteine)-fed group.
C/EBPalpha is an essential regulatory factor for perilipin5 transcription and suggest that fasting stimulates perilipin5 transcription through influencing C/EBPalpha expression.
The differential expression of specific CEBPA/B isoforms observed in maturing follicles and CL may contribute to changes in follicular cell differentiation and increasing steroidogenic capacity.
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.
CCAAT/enhancer-binding protein alpha
, C/EBP alpha
, CAAT/enhancer-binding protein DNA-binding protein
, CAAT/enhancer-binding protein, DNA-binding protein
, CCAAT/enhancer binding protein, alpha
, c/EBP alpha
, CCAAT/enhancer binding protein alpha