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The authors find that KDM3A (zeige KDM3A ELISA Kits) promotes anoikis through transcriptional activation of BNIP3 and BNIP3L (zeige BNIP3L ELISA Kits), which encode pro-apoptotic proteins.
the results suggest that BNIP3 plays a vital role in regulating PINK1 mitochondrial outer membrane localization, the proteolytic process of PINK1 and PINK1/parkin (zeige PARK2 ELISA Kits)-mediated mitophagy under physiological conditions.
High BNIP3 expression is associated with chronic myelogenous leukemia.
Results suggest that changes in mitochondrial morphology and transmembrane potential, induced by mutant htt (zeige HTT ELISA Kits) protein, are dependent and linked to BNip3 and not to Bax (zeige BAX ELISA Kits)/Bak (zeige BAK1 ELISA Kits) activation.
Hypoxia-induced autophagy contributes to the invasion of salivary adenoid cystic carcinoma through the HIF-1alpha (zeige HIF1A ELISA Kits)/BNIP3 signaling pathway.
The data indicated that BNIP3 plays a vital role in the tumorigenesis of adenoid cystic carcinoma and could be a new target for gene therapy of adenoid cystic carcinoma.
BNIP3 deletion can be used as a prognostic (zeige HIF1A ELISA Kits)marker of tumor progression to metastasis in human triple-negative breast cancer
BNIP3 expression was found to be regulated by Sp3 (zeige SP3 ELISA Kits) in prostate cancer.
phosphorylation of these C-terminal BNIP3 residues blocks cell death without preventing autophagy, providing evidence that the two functional roles of BNIP3 can be regulated independently
In a neuronal model of dominant optic atrophy, BNIP3 down-regulation reduced autophagy and mitophagy.
Down-regulation of Bcl2/adenovirus E1B 19-kDa-interacting protein 3 (BNIP3) by olomoucine, a cyclin (zeige PCNA ELISA Kits)-dependent kinasesinhibitor, reduces lipopolysaccharide - and nitric oxide-induced cell death in BV2 (zeige DNAH9 ELISA Kits) microglial cells. Olomoucine may protect cells by limiting proinflammatory responses, thereby reducing nitric oxide generation.
data outline Bnip3 as a key effector of PPARgamma (zeige PPARG ELISA Kits)-mediated adipose mitochondrial network fragmentation, improving insulin (zeige INS ELISA Kits) sensitivity and limiting oxidative stress.
BNIP3 interacts with the mitochondrial outer membrane directly via mitochondrial BAX (zeige BAX ELISA Kits).
Data show that TGFbeta (zeige TGFB1 ELISA Kits)-activated kinase-1 (TAK1 (zeige NR2C2 ELISA Kits)) activated nuclear factor of activated T-cells (NFAT (zeige NFATC1 ELISA Kits))/NF-kappa B (NFkappaB (zeige NFKB1 ELISA Kits)), downregulated BCL2-adenovirus E1B interacting protein 3 (Bnip3), and inhibited cardiac cell death.
propose that BNIP3 acts as a brake on HIF-1 (zeige HIF1A ELISA Kits) activity serving to increase rates of mitophagy in response to hypoxia and to limit production of damaging ROS (zeige ROS1 ELISA Kits) that would further amplify HIF-1 (zeige HIF1A ELISA Kits) expression and promote tumor progression to metastasis
Results suggest that Bnip3 regulates cardiac gene expression and perhaps myocyte morphology by activating nuclear p300 acetyltransferase and hyperacetylating histones and its selective transcription factors.
Bnip3 dual-functionality and crosstalk between mitophagy and apoptosis pathways is presented here.
regulates mitophagy during hypoxia, whereas NIX (zeige BNIP3L ELISA Kits) is required for mitophagy during development of the erythroid lineage.
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein encoded by this gene is known to induce apoptosis, even in the presence of BCL2.
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
, BCL2/adenovirus E1B 19kD-interacting protein 3
, BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP3
, BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP3
, BCL2/adenovirus E1B interacting protein 1, NIP3
, BCL2/adenovirus E1B 19 kDa-interacting protein 3