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Functional studies showed THBS1 and TNC (zeige TNC Proteine) to mediate chemoresistance through the integrin beta1/mTOR (zeige FRAP1 Proteine) pathway.
These findings shed light on the mechanisms leading to beta-cell failure during metabolic stress and point to THBS1 as an interesting therapeutic target to prevent oxidative stress in type 2 diabetes.
Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia.
High plasma levels of TSP-1 are associated with increased pulmonary arterial pressure, increased pulmonary vascular resistance and decreased survival pulmonary hypertension.
Our data suggest that the molecular network including TSP-1, TGF-beta1 (zeige TGFB1 Proteine), and PGE2 might be involved in the pathogenesis of acute angle closure glaucoma.
Genetic variants of THBS1 were significantly more frequent in patients affected by idiopathic/genetic generalized epilepsies than in non-epileptic controls.
In pulmonary hypertension TSP1-CD47 (zeige CD47 Proteine) is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.
High THBS1 expression is associated with primary effusion lymphoma.
Results show that the presence of OPN (zeige SPP1 Proteine) and TSP-1 in the serum of patients with non-small cell lung cancer may reflect the aggressiveness of the tumor.
KLK4 (zeige KLK4 Proteine) further liberated an N-terminal product, with purported angiogenic activity, from thrombospondin-1 (TSP1) and cleaved TSP1 in an osteoblast-derived matrix.
In a laser injury-induced thrombosis model, P-selectin (zeige SELP Proteine) modulates thrombus propagation independently of VWF (zeige VWF Proteine) and TSP1 (zeige GZMA Proteine)
cultured astrocytes isolated from an Fmr1 (zeige FMR1 Proteine) knockout (Fmr1 (zeige FMR1 Proteine) KO) mouse model of Fragile X (zeige FMR1 Proteine) syndrome displayed a significant decrease in TSP-1 (zeige GZMA Proteine) protein expression compared to the wildtype (WT) astrocytes.
In pulmonary hypertension TSP1 (zeige GZMA Proteine)-CD47 (zeige CD47 Proteine) is upregulated, and contributes to pulmonary arterial vasculopathy and dysfunction.
HIF-1alpha (zeige HIF1A Proteine) induced angiogenesis by upregulating not only vascular endothelial growth factor but also miR (zeige MLXIP Proteine)-21 via inhibiting a novel target gene TSP-1 (zeige GZMA Proteine). Both of them may contribute to the protective effect of HIF-1alpha (zeige HIF1A Proteine) on renal I/R injury.
the results obtained by combining bioinformatics and preclinical studies strongly suggest that targeting TSP-1 (zeige GZMA Proteine)/CD47 (zeige CD47 Proteine) axis may represent a valuable therapeutic alternative for hampering melanoma spreading.
TSP-1 (zeige GZMA Proteine) deficiency promotes maladaptive remodelling of the ECM (zeige MMRN1 Proteine) leading to accelerated abdominal aortic aneurysms progression.
TSP-1 (zeige GZMA Proteine) suppressed insulin (zeige INS Proteine) signaling in cultured muscle cells, which was accompanied by the activation of stress signaling such as JNK (zeige MAPK8 Proteine), p38 (zeige CRK Proteine), and IKK (zeige CHUK Proteine).
Three transcription factors were overexpressed and eleven underexpressed in TSP1 (zeige GZMA Proteine)(-/-) compared to WT LGs (zeige LGSN Proteine).
Data indicate that thrombospondin-1 may contribute to a destructive macrophage response in dysferlinopathy and pose the intriguing possibility that thrombospondin-1 levels may serve as a biomarker for disease progression.
Data suggest THBS1 expression predominates in luteal endothelial cells; THBS2 (zeige THBS2 Proteine) expression predominates in luteinized granulosa cells. Luteinization down-regulates expression of THBS1/THBS2 (zeige THBS2 Proteine), up-regulates expression of FGF2 (fibroblast growth factor 2 (zeige FGF2 Proteine)).
Thrombospondin has a role in inducing RhoA (zeige RHOA Proteine) inactivation through FAK (zeige PTK2 Proteine)-dependent signaling to stimulate focal adhesion disassembly
Thrombospondin-1 and -2 were coordinately expressed in the extravascular compartment of the ovary during early follicle development. VEGF was inversely expressed, with expression increasing as follicles developed.
Preincubation of erythroid cells with thrombospondin 1 eliminated the inhibitory activity of insulin (zeige INS Proteine)-like growth factor
The cell-specific regulation of TSP-1 suggests a potential mechanism for the aberrant angiogenesis in diabetics and TSP-1 involvement in development of various vascular diabetic complications
The novel finding that TSP-1-induced migration is dependent on the CD44 (zeige CD44 Proteine) receptor links 2 pathways thought to be disparate (ie, TSP-1 and HyA (zeige KDM5D Proteine)).
These current studies were undertaken to determine how TSP-1 functions to modulate the smooth muscle cell response to IGF-I (zeige IGF1 Proteine) and the mechanisms by which hyperglycemia regulates TSP-1 protein.
Increased TSP-1 expression in non-heart-beating donors may indicate a compensatory response to the reported diminished TGF-beta1 (zeige TGFB1 Proteine) expression.
ELL (zeige ELL Proteine) (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation
The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
, thrombospondin 1
, thrombospondin 2