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Human MAP1LC3B Protein expressed in Wheat germ - ABIN1310156
Martinet, Schrijvers, Timmermans, Bult, De Meyer: Immunohistochemical analysis of macroautophagy: recommendations and limitations. in Autophagy 2013
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the L341V mutation limits the critical step of SQSTM1 (zeige SQSTM1 Proteine) recruitment to the phagophore
LC3B and p62 have roles in autophagy in esophageal adenocarcinoma
Data indicate that tubule-associated protein 1 light chain 3 beta (LC3B) can be potentially useful for identifying autophagosomes and differentiating their developmental stages.
analysis of the RavZ and LC3 (zeige MAP1LC3A Proteine) complex reveals the mechanism for deconjugation of LC3 (zeige MAP1LC3A Proteine) on the phagophore membrane
SQSTM1 is ubiquitinated by NEDD4 while LC3 functions as an activator of NEDD4 ligase activity.
Cardiolipin interaction with various Atg8 (zeige GABARAPL2 Proteine) human orthologs, namely LC3B, GABARAPL2 (zeige GABARAPL2 Proteine) and GABARAP (zeige GABARAP Proteine), was investigated.
Insights into links between autophagy and the ubiquitin system showed that LC3B-binding can steer intrinsic NEDD4 E3 ligase activity.
Determined is the three-dimensional crystal structures of LC3B in complex with three different LIR (zeige CD300C Proteine) motifs of RavZ from Legionella pneumophila, an intracellular pathogen that can manipulate the host autophagy system.
We found that 25-epi (zeige TFPI Proteine) Ritterostatin GN1N induced cell death in melanoma cells at nanomolar concentrations, and this cell death was characterized by inhibition of GRP78 (zeige HSPA5 Proteine) expression, increased expression of the ER stress marker CHOP (zeige DDIT3 Proteine), loss of mitochondrial membrane potential, and lipidation of the autophagy marker protein LC3B.
Double IF showed the co-localization of AQP5 (zeige AQP5 Proteine) and LC3B on BafA1-treated heated cells. In conclusion, we demonstrated that heat shock decreased AQP5 (zeige AQP5 Proteine) on cellular membranes and in the cytoplasm by activating autophagic degradation, and heat shock and AQP5 (zeige AQP5 Proteine) knockdown exerted similar anticancer effects, suggesting that heat shock exerts anticancer effects via the autophagic degradation of AQP5 (zeige AQP5 Proteine).
The crystal structure of mouse LC3B in complex with the FYCO1 (zeige FYCO1 Proteine) LC3 (zeige MAP1LC3A Proteine)-interacting region (LIR (zeige CD300C Proteine)) reveals the importance of the flanking region of the LIR (zeige CD300C Proteine) motif.
Data suggest that maternal nutrition modulates expression of autophagy proteins p62/Sqstm1 (zeige SQSTM1 Proteine) and Lc3 (zeige MAP1LC3A Proteine)-II/Map1lc3 in liver and hypothalamus of offspring (newborn, suckling, and adult stages); for example, high-fat diet leading to maternal obesity up-regulates p62 (zeige GTF2H1 Proteine) and down-regulates Lc3 (zeige MAP1LC3A Proteine)-II in neonatal liver. (p62/Sqstm1 (zeige SQSTM1 Proteine) = sequestosome 1 (zeige SQSTM1 Proteine); Lc3 (zeige MAP1LC3A Proteine)-II/Map1lc3 = microtubule-associated protein (zeige SPAG5 Proteine) 1-light chain 3)
Treatment of aged mice and their derived macrophages with methyltransferase inhibitor (2)-epigallocatechin-3-gallate (EGCG) or specific DNA methyltransferase 2 (DNMT2 (zeige TRDMT1 Proteine)) siRNA restored the expression of Atg5 (zeige ATG5 Proteine) and LC3 (zeige MAP1LC3A Proteine) in vivo and in vitro.
MREG (zeige MREG Proteine)-dependent processing links both autophagic and phagocytic processes in LC3 (zeige MAP1LC3A Proteine)-associated phagocytosis. MREG (zeige MREG Proteine) participates in coordinating the association of phagosomes with LC3 (zeige MAP1LC3A Proteine) for content degradation with the MREG (zeige MREG Proteine) loss leading to phagosome accumulation.
This work identifies a previously unrecognized role for alphav and the autophagy components LC3 and atg5 in regulating TLR signalling and B-cell immunity.
Deficiency of autophagy protein Map1 (zeige MOAP1 Proteine)-LC3b mediates IL-17 (zeige IL17A Proteine)-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1 (zeige IL1A Proteine).
This study suggests that autophagy could play a role in placental invasion system and that nutrient starvation affects LC3B expression.
Data indicate that the recombinant plasmid encoding pCMV-LC3 (zeige MAP1LC3A Proteine)-LpqH could be a practical strategy for the development of improved vaccines against Mycobacterium tuberculosis.
Lipidation of the LC3 (zeige MAP1LC3A Proteine)/GABARAP (zeige GABARAP Proteine) family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3 (zeige ATG3 Proteine).
p62 (zeige GTF2H1 Proteine)/LC3b complex regulates lung alveolar epithelial cell homeostasis and cytoprotection after hyperoxia.
Data indicate that the expression of MAP1LC3A (zeige MAP1LC3A Proteine), B and autophagy-associated genes (ATG5 (zeige ATG5 Proteine), mTOR (zeige FRAP1 Proteine), Beclin-1 (zeige BECN1 Proteine)) was increased in normal pigs, while decreased in miniature pigs.
The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component.
MAP1 light chain 3-like protein 2
, MAP1A/MAP1B LC3 B
, MAP1A/MAP1B light chain 3 B
, autophagy-related ubiquitin-like modifier LC3 B
, microtubule-associated proteins 1A/1B light chain 3B
, MAP1A/1B light chain 3 B
, autophagy-related protein LC3 B
, microtubule-associated proteins 1A/1B light chain 3
, microtubule-associated protein 1 light chain 3 beta