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CITP, PIIINP, and P4NP 7S do not reflect myocardial collagen mRNA expression but presumably reflect extra-cardiac organ injury in heart failure.
Elevated circulating PIIINP levels are associated with type 2 diabetes mellitus individuals with adipose tissue expansion and systemic proinflammatory profile suggestive for adipose tissue dysfunction.
Reduced expression of types I and III collagen and TIMP-1 as well as the increased expression of MMP-1 and MMP-8 in the anterior vaginal wall tissues play important roles in the onset of pelvic organ prolapse.
a variant of COL3A1 (rs3134646) is associated with the risk of developing colonic diverticulosis in white men, whereas rs1800255 (COL3A1) and rs1800012 (COL1A1) were not associated with this condition after adjusting for confounding factors.
Brain MRI in the affected siblings as well as in the two previously reported individuals with bi-allelic COL3A1 mutations showed a brain phenotype similar to that associated with mutations in GPR56.
Given the high specificity of the polymorphism at the rs1800255 locus of the COL3A1 gene, determined by the Sanger sequencing, it can be concluded that there is an association between this polymorphism and urinary incontinence and pelvic organ prolapse in women.
Case Report: novel missense COL3A1 mutation in vascular Ehlers-Danlos syndrome patient presenting with pulmonary complications and iliac arterial dissection.
Kaplan-Meir analysis of GSE7696 indicate that COL3A1 and SNAP91 correlated with survival.
provide a picture of the gene expression changes in vascular Ehlers-Danlos syndrome skin fibroblasts and highlight that dominant negative mutations in COL3A1 also affect post-translational modifications and deposition into the ECM of several structural proteins crucial to the integrity of soft connective tissues
Abnormal regulation of COL1 and COL3 may contribute to the early predisposition to POP in premenopausal women.
We identified biallelic COL3A1 variants in two unrelated families. In a 3-year-old female with developmental delay the nonsense variant c.1282C>T, p.(Arg428*) was detected in combination the c.2057delC, p.(Pro686Leufs*105) frame shift variant.
In conclusion, based on serological collagen formation and degradation makers, penetrating Crohn's disease is associated with increased matrix metalloproteinase-9 mediated breakdown of type III collagen
Col3A may be a potential adjunct marker for both differentiating fibroadenoma from phyllodes tumor and assessing malignant potential in PTs.
Case Report: pathogenetic heterozygous COL3A1 mutation c.3140 G>A, p. Gly1047Asp in Ehlers-Danlos syndrome vascular type with different phenotypes in the same family.
von Willebrand factor A1 domain-collagen binding is independent of gain- or loss-of-function phenotype and under shear stress, platelet translocation pause times on collagen-bound A1A2A3 are either normal or shorter depending on whether A1 is concertedly bound with the A3 domain to collagen.
High serum procollagen type III N-terminal peptide expression is associated with non-alcoholic fatty liver disease.
The findings indicate the critical role of CatB in regulating the expression of collagens III and IV by fibroblasts via prolonging TLR2/NF-kappaB activation and oxidative stress.
High COL3A1 expression is associated with colorectal carcinoma.
Data show that emodin can block pulmonary fibroblast proliferation and differentiation into myofibroblasts, and reduce the synthesis of collagen type 1 (Col1) and collagen type 3 (Col3).
novel missense mutation c.2176G>C in Chinese family with vascular Ehlers-Danlos syndrome
Results show that COL1A1 and COL3A1 expression is up-regulated in Schistosoma japonicum-induced liver fibrosis. Furthermore, miR-29b directly targets COL1A1 and COL3A1 through binding to their 3'UTR.
findings suggest that deficiencies of leucine and isoleucine reduce type I and III tropocollagen syntheses in skin by suppressing the action of mTOR
osthole could inhibit the collagen I and III expressions and their ratio in CFs treated with TGF-beta1 via Smad signaling pathway, which might be one of its anti-fibrotic action mechanisms.
Tsk2 expressing mice harbor numerous autoantibodies in their plasma, including some which are similar to antinuclear antibodies present in systemic sclerosis patients.
Tight skin 2 mice exhibit a novel time line of events leading to increased extracellular matrix deposition and dermal fibrosis.
Procollagen type III amino-terminal propeptide increases with left ventricular dilation and decreases with improvement in systolic function in paediatric dilated cardiomyopathy, indicating a role as a biomarker of cardiac remodelling in children.
Tsk2 point mutation is the first documented gain-of-function mutation associated with Col3a1, which leads instead to fibrosis.
Col3 plays a role in development of trabecular bone through its effects on osteoblast differentiation
Type I collagen turnover is critical to large pulmonary artery remodeling during hypoxic pulmonary hypertension when collagen metabolism is not mutated and type III collagen may serve as a reserve.
Our findings demonstrated the extreme sensitivity of Col3a1 insufficient mice to prematurely develop thoracic aortic ruptures in response to AngII and its associated high levels in BP.
a possible common pathological pathway linking connective tissue diseases and brain malformations
Data show that that Col3a1 null mutant mice exhibit overmigration of neurons beyond the pial basement membrane and a cobblestone-like cortical malformation similar to the phenotype seen in Gpr56 null mutant mice.
Diminished type III collagen promotes myofibroblast differentiation and increases scar deposition in cutaneous wound healing
Spontaneous deletion in the promoter region and exons 1-39 of the murine Col3a1 locus has produced a relevant and exploitable model of the vascular dissection in vascular Ehlers-Danlos syndrome.
Data indicate that COL3A1 intronic miRNAs may regulate the expression of other collagen genes in development.
Transcriptional activation in Tsk2/+ dermal fibroblasts.
This study shows the presence of collagen types I, III, and V in the endometrial stroma of implantation and interimplantation sites from days 5 to 8 of pregnancy in the mouse.
alterations in procollagen expression (specifically 1alpha1 and 3) may contribute to a pattern of collagen deposition in the mid-gestational fetuses that is more favorable for scarless healing with less type 1 and more type 3 collagen.
decreased expression in late-gestational fibroblasts
specific ADAMTS-2 domains cleave the aminopropeptide of fibrillar procollagens types I-III and V
The present results suggest that not only type III collagen but also cartilage oligomeric matrix protein is involved in the repair and remodeling processes of the digital flexor tendon.
transcript decreased by 42.3-fold compared with uninjured skin after pressure treatment, whereas a 1.3-fold increase was seen in untreated scars
Ammonium perchlorate can increase gene expressions of types I, III collagens, TGF-beta(1) and TNF-alpha in lung of rabbits.
This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
Ehlers-Danlos syndrome type IV, autosomal dominant
, alpha1 (III) collagen
, collagen alpha-1(III) chain
, collagen, fetal
, minisatellite 10w detected by probe MMS10
, procollagen, type III, alpha 1
, alpha 1 type III collagen
, collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant)
, collagen alpha 1 type III
, collagen, type III, alpha 1 chain, fibril forming
, collagen alpha-1(III) chain preproprotein
, collagen type III alpha 1
, procollagen alpha-1 type III
, collagen, type III, alpha 1
, type III collagen
, pro-alpha-1 type 3 collagen
, collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) S homeolog