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In high-grade serous ovarian carcinoma patients, MAL was overexpressed in platinum-resistant compared to platinum-sensitive patients and resulted as an independent prognostic marker of survival.
MAL and TMEM220 were specifically methylated and were down-regulated in human gastric cancer.
This study revealed that Merkel cell polyomavirus -negative Merkel cell carcinomas significantly expressed higher CADM1 and lower MAL than Merkel cell polyomavirus -positive Merkel cell carcinomas
CADM1/MAL methylation increases with severity of cervical intraepithelial neoplasia
Hypermethylation of the selected markers (MAL, PRIMA1, PTGDR and SFRP1) can result in reduced gene expression and may contribute to the formation of colorectal cancer.
Data suggest that expression of MAL in cells confers both ETX (Clostridium perfringens epsilon-toxin) binding and susceptibility to ETX-mediated cell death; cells expressing rat MAL are 100 times more sensitive to ETX than cells expressing human MAL.
The use of CADM1, MAL, and MIR124-2 as biomarkers for full molecular screening in HIV infected women who are also positive for human papillomavirus.
MAL is a critical element of the machinery for exosome secretion and may constitute a target for modulating exosome secretion by human T cells.
MAL hypermethylation is associated with esophageal carcinoma progression.
Cytology and bi-marker CADM1/MAL-methylation analysis perform complementary for CIN2+/CIN3+ detection when used as triage tool on cervical scrapes of HPV positive women.
DNA methylation analysis of CADM1, MAL and miR124-2 in cervical scrapes consistently detects cervical cancer
The MAL gene repression related with lymph node metastasis and poor prognosis in gastric cancer, suggesting that the MAL may be a new candidate node metastasis-suppressor gene for gastric cancer.
CADM1 and MAL methylation levels increased proportional to severity of the underlying lesion
hypomethylation of LINE-1 and hypermethylation of SLIT2, MAL and IGFBP7 were frequently detected in NSCLCs and associated with various clinical features.
MAL protein plays an important role during oral carcinogenesis, MAL gene expression was significantly decreased in oral squamous cell carcinoma compared with normal epithelium.
Data indicate that DNA methylation status of multiple genes CADM1, MAL and hsa-miR-124-2 was analyzed in human papillomavirus (hrHPV)-positive cervical scrape.
the methylation marker panel CADM1-M18 and MAL-M1 may serve as an alternative molecular triage tool for hrHPV-positive women.
Data show that a combination of CADM1 and MAL methylation could represent a promising candidate triage tool for hrHPV-positive women.
Data show that MAL regulates membrane order and the distribution of microtubule and transport vesicle docking machinery at the IS and, by doing so, ensures correct protein sorting of Lck and LAT to the cSMAC.
MAL is normally expressed in laryngeal epithelial cells and its expression changes at early stages of carcinoma development.
Expression of the developmentally regulated proteolipid MAL is required for the cytotoxic effect of Clostridium perfringens Epsilon Toxin.
MAL overexpression leads to reduced expression of Mpz and p75NTR, despite functional pathways and normal expression of genes important for Schwann cell differentiation.
VIP17/MAL overexpression results in abnormal cilium and cyst development, in vitro and in vivo, and in VIP17/MAL-overexpressing mice that develop cysts secondary to a ciliary defect.
the exclusion of MAL from the expanding 2D crystals of uroplakins explains the selective association of MAL with the hinge areas in the uroplakin-delivering fusiform vesicles, as well as at the apical surface
Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling.
The specific reduction and mistargeting of MAL protein as a reaction to sulfatide overload may contribute to the pathogenic mechanisms in metachromatic leukodystrophy.
Our results demonstrate a critical role for MAL in the maintenance of central nervous system paranodes, likely by controlling the trafficking and/or sorting of NF155 and other membrane components in oligodendrocytes.
Our results suggest a functional role for MAL in peripheral myelination by influencing the expression of membrane components that mediate axon-glia interaction during ensheathment and myelin wrapping.
SYP is an hexameric MAL-domain channel protein.
The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3.
T-lymphocyte maturation-associated protein
, myelin and lymphocyte protein
, myelin and lymphocyte protein, T-cell differentiation protein
, Myelin and lymphocyte protein
, 17 kDa myelin vesicular protein
, NS 3
, VIP17 proteolipid
, VIP17/MAL proteolipid
, MAL-like protein