Telefon:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antikoerper-online.de

Morbus Stargardt

Stargardt disease (STGD) is the most prevalent inherited macular dystrophy and is associated with disease-causing sequence variants in the gene ABCA4. Significant advances have been made over the last 10 years in our understanding of both the clinical and molecular features of STGD1, and also the underlying pathophysiology, which has culminated in ongoing and planned human clinical trials of novel therapies.(1) Mutations in four genes have been linked with Stargardt disease: ABCA4, ELOVL4, PROM1, CNGB3.

ABCA4 Antibody cited in Stargardt Disease Gene Therapy Article

McClements et al. investigate use of dual vector approach for AAV Gene Therapy of Stargardt disease. anti-ABCA4 antibody (ABIN343052) cited in Human Gene Therapy Vol. 30, No. 5. (2019)

Show more

Important Targets related to Stargardt disease

The following targets are directly related to research on Stargardt disease. Click on the links to see available antibodies, kits, proteins, and tools.

ABCA4 Antibodies

Autosomal recessive retinal diseases caused by mutations in the ABCA4 gene are being considered for gene replacement therapy. All individuals with ABCA4-disease show macular degeneration.(2)

Produkt
Reaktivität
Klonalität
Applikation
Kat. Nr.
Menge
ReaktivitätCow
KlonalitätMonoclonal
ApplikationIHC, WB
Kat. Nr.ABIN361347
Menge100 μL
ReaktivitätHuman
KlonalitätPolyclonal
ApplikationELISA, WB
Kat. Nr.ABIN343052
Menge100 μg

ELOVL4 Antibodies

Autosomal dominant Stargardt macular dystrophy caused by mutations in the Elongation of Very Long Chain fatty acids (ELOVL4) gene results in macular degeneration, leading to early childhood blindness.(3)

Produkt
Reaktivität
Klonalität
Applikation
Kat. Nr.
Menge
ReaktivitätHuman
KlonalitätPolyclonal
ApplikationWB
Kat. Nr.ABIN1679709
Menge100 μg
ReaktivitätHuman, Mouse
KlonalitätPolyclonal
ApplikationELISA, ICC, IF, WB
Kat. Nr.ABIN6258771
Menge100 μL
ReaktivitätHuman, Mouse
KlonalitätPolyclonal
ApplikationELISA, WB
Kat. Nr.ABIN3184467
Menge100 μL

PROM1 Antibodies

Prominin-1 (Prom1) is a transmembrane glycoprotein, which is expressed in stem cell lineages, and has recently been implicated in cancer stem cell survival. Mutations in the Prom1 gene have been shown to disrupt photoreceptor disk morphogenesis and cause an autosomal dominant form of Stargardt-like macular dystrophy (STGD4).(4)

Produkt
Reaktivität
Klonalität
Applikation
Kat. Nr.
Menge
ReaktivitätHuman
KlonalitätMonoclonal
ApplikationFACS, ICC, WB
Kat. Nr.ABIN6559826
Menge100 tests
ReaktivitätHuman
KlonalitätMonoclonal
ApplikationFACS, IHC, WB
Kat. Nr.ABIN6559814
Menge0.1 mg
ReaktivitätHuman
KlonalitätMonoclonal
ApplikationFACS, IHC, WB
Kat. Nr.ABIN6559833
Menge100 tests

We offer custom Made-to-order Proteins

We support you with high-purity made-to-order proteins with native state folding guarantee. Please contact us via email, chat, or phone for more information.

Produkt
Protein Type
Conjugate
Kat. Nr.
Menge
Protein TypeRecombinant
ConjugateHis tag
Kat. Nr.ABIN3087964
Menge1 mg
Protein TypeRecombinant
ConjugateHis tag
Kat. Nr.ABIN3136754
Menge1 mg
Protein TypeRecombinant
ConjugateHis tag
Kat. Nr.ABIN3077722
Menge1 mg
Protein TypeRecombinant
Conjugaterho-1D4 tag
Kat. Nr.ABIN3092348
Menge0.5 mg
Protein TypeRecombinant
ConjugateHis tag
Kat. Nr.ABIN3086478
Menge1 mg
Protein TypeRecombinant
ConjugateHis tag
Kat. Nr.ABIN3082621
Menge1 mg

antibodies-online.com: Making the Complex Convenient

  • Target Coverage: 330 Stargardt Disease-related antibodies, proteins, ELISA kits covering all relevant targets
  • Product Search: Extensive filtering options and comprehensive product details leading to the right choice
  • Order Fulfillment: Trusted Supplier to 10000+ Institutions with Customer Service Hubs in US and Europe

References:

  • (1) Tanna P, Strauss RW, Fujinami K, Michaelides M. Stargardt disease: clinical features, molecular genetics, animal models and therapeutic options. Br J Ophthalmol. 2017 Jan;101(1):25-30. doi: 10.1136/bjophthalmol-2016-308823. Epub 2016 Aug 4. PMID: 27491360; PMCID: PMC5256119.
  • (2) Cideciyan AV, Swider M, Aleman TS, Tsybovsky Y, Schwartz SB, Windsor EA, Roman AJ, Sumaroka A, Steinberg JD, Jacobson SG, Stone EM, Palczewski K. ABCA4 disease progression and a proposed strategy for gene therapy. Hum Mol Genet. 2009 Mar 1;18(5):931-41. doi: 10.1093/hmg/ddn421. Epub 2008 Dec 12. PMID: 19074458; PMCID: PMC2640207.
  • (3) Agbaga MP, Tam BM, Wong JS, Yang LL, Anderson RE, Moritz OL. Mutant ELOVL4 that causes autosomal dominant stargardt-3 macular dystrophy is misrouted to rod outer segment disks. Invest Ophthalmol Vis Sci. 2014 May 15;55(6):3669-80. doi: 10.1167/iovs.13-13099.
  • (4) Bhattacharya S, Yin J, Winborn CS, Zhang Q, Yue J, Chaum E. Prominin-1 Is a Novel Regulator of Autophagy in the Human Retinal Pigment Epithelium. Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):2366-2387. doi: 10.1167/iovs.16-21162.
Sie sind hier: