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In AML (zeige RUNX1 Proteine) patients, low level of miR (zeige MLXIP Proteine)-451 is negatively correlated with high levels of c-Myc (zeige MYC Proteine) and YWHAZ, while c-Myc (zeige MYC Proteine) level is positively related to YWHAZ expression. These results suggested that c-Myc (zeige MYC Proteine) dash, verticalmiR-451 dash, verticalYWHAZ/AKT (zeige AKT1 Proteine) cascade might play a crucial role during leukemogenesis, and reintroduction of miR (zeige MLXIP Proteine)-451 could be as a potential strategy for AML (zeige RUNX1 Proteine) therapy.
miR (zeige MLXIP Proteine)-22 exhibits tumor-suppressive effects in hepatocellular carcinoma cells by regulating YWHAZ/AKT (zeige AKT1 Proteine)/FOXO3a (zeige FOXO3 Proteine) signaling.
our data demonstrate that overexpression of 14-3-3zeta in early stage pre-cancerous breast epithelial cells may trigger an elevated glycolysis and transcriptionally up-regulating LDHA (zeige LDHA Proteine), thereby contributes to human breast cancer initiation.
14-3-3zeta can bind to the FOXO3a (zeige FOXO3 Proteine) transcription factor to promote the export of the complex to the cytoplasm, leading to enhanced proliferation and migration of tongue cancer cells.
Structure of the complex of phosphorylated liver kinase B1 (zeige STK11 Proteine) and 14-3-3zeta has been reported.
These results suggest that the hypoxia/14-3-3zeta/HIF-1alpha (zeige HIF1A Proteine) pathway plays an important role in portal vein tumor thrombus formation and hepatocellular carcinoma metastasis
14-3-3zeta recruited YAP and p-LATS to form a complex under high cells density status and 14-3-3zeta other than YAP or phospho-LATS was the key regulatory molecule of this complex.
This study shows that human procaspase-2 interaction with 14-3-3 zeta is governed by phosphorylation at both S139 and S164.
The results highlight a new role of TSC2 in protecting glioblastoma against photodynamic therapy-induced cell death, and TSC2 and YWHAZ as new RIP3 (zeige RIPK3 Proteine) partners.
These results suggest that 14-3-3-zeta is involved in the TLR3 (zeige TLR3 Proteine)-TICAM-1 (zeige TICAM1 Proteine) pathway in promoting multimerization of TICAM-1 (zeige TICAM1 Proteine) for the formation of a TICAM-1 (zeige TICAM1 Proteine) signalosome.
The expression of zeta isoforms of 14-3-3 protein (zeige YWHAE Proteine) was identified at substantial levels in the first instar larva, upregulated in the second instar larva, and the highest levels were maintained in the late stage of larva, the pupa, and the adult.
Caspase-2 (zeige CASP2 Proteine) phosphorylated at S135 binds 14-3-3zeta, thus preventing C2 dephosphorylation.
identification of 14-3-3zeta as a novel phosphocofilin binding protein involved in the maintenance of the cellular phosphocofilin pool
DEX can increase IOP in mouse eyes and concurrently downregulate 14-3-3 zeta protein expression in mouse TM
These results demonstrate that miR (zeige MLXIP Proteine)-146a enhances class switch and secretion of IgE in B cells by upregulating 14-3-3sigma expression, and suggest that miR (zeige MLXIP Proteine)-146a may be a potential target for asthma therapy.
When taken together these findings demonstrate novel roles of 14-3-3zeta in the regulation of glucose homeostasis and suggest that modulating 14-3-3zeta levels in intestinal L cells may have beneficial metabolic effects through GLP-1 (zeige GCG Proteine)-dependent mechanisms.
The data obtained from the 14-3-3epsilon/14-3-3zeta/Wnt1 (zeige WNT1 Proteine)-Cre mice strongly indicate the importance of 14-3-3 (zeige YWHAQ Proteine) proteins in the development of melanocyte lineages.
Results indicate that HuR (zeige ELAVL1 Proteine) induces 14-3-3zeta translation via interaction with its 3' UTR and that 14-3-3zeta is necessary for stimulation of intestinal epithelial cell migration after wounding.
PKCdelta (zeige PKCd Proteine)-mediated phosphorylation of 14-3-3zeta contributes to the nuclear retention of FOXO1 (zeige FOXO1 Proteine), even when FOXO1 (zeige FOXO1 Proteine) is phosphorylated as under non-stress conditions
analysis of phosphorylation-dependent interactions of AQP2 (zeige AQP2 Proteine) with 14-3-3theta; and -zeta
14-3-3zeta deficient mice in the BALB/c background display behavioral and anatomical defects associated with Schizophrenia-like disorder.
Ywhaz coordinates adipogenesis in visceral fat.
An essential role for 14-3-3 zeta in the regulation of macropinocytosis in macrophages upon cytokine stimulation through modulation of the localization of coronin 1.
Comparison of day 25 Meishan and white composite swine placentas by microarray expression profiling revealed a breed-specific transition expression polymorphism in YWHAZ.
The Khc73 stalk/14-3-3/NudE pathway defines a physical connection that coordinates the activities of multiple motor proteins to precisely position the spindle.
Hpo (zeige GFER Proteine) signaling inhibited Yki (zeige YAP1 Proteine) nuclear localization and activity by phosphorylating Yki (zeige YAP1 Proteine) and both isoforms of 14-3-3, 14-3-3varepsilon and 14-3-3zeta, regulate Yki (zeige YAP1 Proteine) activity through modulating its subcellular localization.
in vivo 14-3-3zeta monomer properties and functionality
monomeric D14-3-3zeta is capable of modulating dSlo channel activity in this regulatory complex.
These observations provide the first direct evidence that a 14-3-3 protein (zeige YWHAE Proteine) functions as a stress-induced molecular chaperone (zeige HSP90AA1 Proteine) that dissolves and renaturalizes thermal-aggregated proteins.
Results report a bona fide third functional isoform encoded by leo divergent from the other two in structurally and functionally significant areas.
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.
, 14-3-3 protein zeta/delta
, 14-3-3 protein/cytosolic phospholipase A2
, 14-3-3 zeta
, phospholipase A2
, protein kinase C inhibitor protein 1
, protein kinase C inhibitor protein-1
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide
, tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide
, 14-3-3 protein zeta
, tyrosine 3-monooxygenase protein zeta polypeptide
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide b
, factor activating exoenzyme S
, mitochondrial import stimulation factor S1 subunit
, 14-3-3 protein zeta a
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide a
, tyrosine 3/tryptophan 5-monooxygenase activation protein zeta polypeptide
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide
, D14 3 3 protein
, complementation group K
, leonardo 14-3-3
, tyrosine 3-monooxygenase
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide