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16.88187 | ABIN2749025 | Func IHC (f) FACS WB | Mouse | IgG2b | Anmelden zum Anzeigen | ITEM-4 | 3 | |||
16.88187 | ABIN2749054 | Func IHC (f) FACS WB | Mouse | IgG2b | Anmelden zum Anzeigen | ITEM-4 | 3 |
General |
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Antigen | Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) Antikörper |
Reaktivität | Human, Maus Alternativen |
Wirt | Maus Alternativen |
Klonalität (Klon) | |
Konjugat | Dieser TNFRSF12A Antikörper ist konjugiert mit PE Alternativen |
Applikation |
Functional Studies (Func), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Flow Cytometry (FACS), Western Blotting (WB)
Alternativen
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3 Publikationen vorhanden |
Hersteller | Anmelden zum Anzeigen |
Produktdetails anti-TNFRSF12A AntikörperTarget Details TNFRSF12A Anwendungsinformationen Handhabung Referenzen für anti-TNFRSF12A Antikörper (ABIN2749122) Bilder |
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Spezifität | The mouse monoclonal antibody ITEM-4 recognizes CD266 / TWEAK R, a TNFR superfamily receptor for CD255 / TWEAK, a TNF-like weak inducer of apoptosis. |
Kreuzreaktivität (Details) | Human, Mouse |
Immunogen | human CD266-transfected P815 cells |
Klon | ITEM-4 |
Isotyp | IgG2b |
Plasmids, Primers & others | |
Target Details TNFRSF12AProduktdetails anti-TNFRSF12A Antikörper Anwendungsinformationen Handhabung Referenzen für anti-TNFRSF12A Antikörper (ABIN2749122) Bilder zurück nach oben |
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Antigen | |
Andere Bezeichnung | CD266 / TWEAK R (TNFRSF12A Antibody Abstract) |
Hintergrund | CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential. |
Pathways | Apoptose, Regulation of Cell Size |
AnwendungsinformationenProduktdetails anti-TNFRSF12A Antikörper Target Details TNFRSF12A Handhabung Referenzen für anti-TNFRSF12A Antikörper (ABIN2749122) Bilder zurück nach oben |
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Applikations-hinweise | The reagent is designed for Flow Cytometry analysis. |
Kommentare |
The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
Beschränkungen | Nur für Forschungszwecke einsetzbar |
HandhabungProduktdetails anti-TNFRSF12A Antikörper Target Details TNFRSF12A Anwendungsinformationen Referenzen für anti-TNFRSF12A Antikörper (ABIN2749122) Bilder zurück nach oben |
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Buffer | The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide. |
Konservierungs-mittel | Sodium azide |
Vorsichtsmaßnahmen | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Lagerung | 4 °C |
Informationen zur Lagerung | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label. |
Referenzen für anti-TNFRSF12A Antikörper (ABIN2749122)Produktdetails anti-TNFRSF12A Antikörper Target Details TNFRSF12A Anwendungsinformationen Handhabung Bilder zurück nach oben |
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Produkt verwendet in: |
Yoriki, Akashi, Sho, Nomi, Yamato, Hotta, Takayama, Matsumoto, Wakatsuki, Migita, Yagita, Nakajima: "Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer." in: Experimental and therapeutic medicine, Vol. 2, Issue 1, pp. 103-108, 2012 Roos, Wicovsky, Müller, Salzmann, Rosenthal, Kalthoff, Trauzold, Seher, Henkler, Kneitz, Wajant: "Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 3, pp. 1593-605, 2010 Nakayama, Ishidoh, Kojima, Harada, Kominami, Okumura, Yagita: "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 1, pp. 341-8, 2002 |
BilderProduktdetails anti-TNFRSF12A Antikörper Target Details TNFRSF12A Anwendungsinformationen Handhabung Referenzen für anti-TNFRSF12A Antikörper (ABIN2749122) zurück nach oben |
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Bilder des Herstellers |