anti-Human TNFRSF12A Antikörper für Immunohistochemistry (Formalin-fixed Sections)

Recommended TNFRSF12A Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) Antikörper
  • CD266
  • FN14
  • TWEAKR
  • AI255180
  • C87282
  • Fn14
  • HPIP
  • TWEAK-R
  • TweakR
  • TNF receptor superfamily member 12A
  • tumor necrosis factor receptor superfamily, member 12a
  • TNFRSF12A
  • Tnfrsf12a
Reaktivität
Human, Maus
90
59
30
3
3
2
2
2
2
1
1
1
Wirt
Maus
47
42
9
1
Klonalität
Monoklonal
Konjugat
Dieser TNFRSF12A Antikörper ist unkonjugiert
11
4
4
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Applikation
Functional Studies (Func), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Flow Cytometry (FACS), Western Blotting (WB)
55
46
27
15
13
12
10
10
3
2
2
2
2
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Produktnummer ABIN2749025
$ 253.00
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN2749122 Func IHC (f) FACS WB PE Mouse IgG2b Anmelden zum Anzeigen ITEM-4 3
1 ABIN2749054 Func IHC (f) FACS WB Mouse IgG2b Anmelden zum Anzeigen ITEM-4 3

General

Antigen Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A) Antikörper
Reaktivität Human, Maus
(90), (59), (30), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Wirt Maus
(47), (42), (9), (1)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser TNFRSF12A Antikörper ist unkonjugiert
(11), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Functional Studies (Func), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Flow Cytometry (FACS), Western Blotting (WB)
(55), (46), (27), (15), (13), (12), (10), (10), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Pubmed 3 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-TNFRSF12A Antikörper

Target Details TNFRSF12A Anwendungsinformationen Handhabung Referenzen für anti-TNFRSF12A Antikörper (ABIN2749025) Bilder
Spezifität The mouse monoclonal antibody ITEM-4 recognizes CD266 / TWEAK R, a TNFR superfamily receptor for CD255 / TWEAK, a TNF-like weak inducer of apoptosis.
Reinigung Purified from cell culture supernatant by protein-A affinity chromatography.
Reinheit > 95 % (by SDS-PAGE)
Sterilität 0.2 μm filtered
Endotoxin-Niveau Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.
Immunogen human CD266-transfected P815 cells
Klon ITEM-4
Isotyp IgG2b
Plasmids, Primers & others

Target Details TNFRSF12A

Produktdetails anti-TNFRSF12A Antikörper Anwendungsinformationen Handhabung Referenzen für anti-TNFRSF12A Antikörper (ABIN2749025) Bilder zurück nach oben
Antigen
Andere Bezeichnung CD266 / TWEAK R (TNFRSF12A Antibody Abstract)
Hintergrund CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential.
Pathways Apoptose, Regulation of Cell Size

Anwendungsinformationen

Produktdetails anti-TNFRSF12A Antikörper Target Details TNFRSF12A Handhabung Referenzen für anti-TNFRSF12A Antikörper (ABIN2749025) Bilder zurück nach oben
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-TNFRSF12A Antikörper Target Details TNFRSF12A Anwendungsinformationen Referenzen für anti-TNFRSF12A Antikörper (ABIN2749025) Bilder zurück nach oben
Buffer Azide free phosphate buffered saline (PBS), approx. pH 7.4
Konservierungs-mittel Azide free
Lagerung 4 °C
Informationen zur Lagerung Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.

Referenzen für anti-TNFRSF12A Antikörper (ABIN2749025)

Produktdetails anti-TNFRSF12A Antikörper Target Details TNFRSF12A Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Yoriki, Akashi, Sho, Nomi, Yamato, Hotta, Takayama, Matsumoto, Wakatsuki, Migita, Yagita, Nakajima: "Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer." in: Experimental and therapeutic medicine, Vol. 2, Issue 1, pp. 103-108, 2012

Roos, Wicovsky, Müller, Salzmann, Rosenthal, Kalthoff, Trauzold, Seher, Henkler, Kneitz, Wajant: "Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 3, pp. 1593-605, 2010

Nakayama, Ishidoh, Kojima, Harada, Kominami, Okumura, Yagita: "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 1, pp. 341-8, 2002