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Whole exome sequencing (WES) of an affected fetus, and subsequent Sanger sequencing of the second fetus, revealed a homozygous frameshift variant in CRADD, which encodes an adaptor protein that interacts with PIDD (zeige PIDD ELISA Kits) and caspase-2 (zeige CASP2 ELISA Kits) to initiate apoptosis
The megalencephaly, lissencephaly variant, and intellectual disability associated with loss of CRADD/caspase-2 (zeige CASP2 ELISA Kits)-mediated apoptosis imply a role for CRADD/caspase-2 (zeige CASP2 ELISA Kits) signaling in development of the human cerebral cortex.
The adaptor molecule RAIDD coordinates IKKepsilon (zeige IKBKE ELISA Kits) and IRF7 (zeige IRF7 ELISA Kits) interaction to ensure efficient expression of type I interferon (zeige IFNA ELISA Kits).
define a novel function for CRADD in endothelial cells as an inducible suppressor of BCL10, a key mediator of responses to proinflammatory agonists
Study identified sequence variants in the known disease-causing genes SLC6A3 (zeige SLC6A3 ELISA Kits) and FLVCR1 (zeige FLVCR1 ELISA Kits), and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6 (zeige TUBGCP6 ELISA Kits), BRAT1 (zeige C7orf27 ELISA Kits), SNIP1 (zeige SNIP1 ELISA Kits), CRADD, and HARS (zeige HARS ELISA Kits).
point mutations on RAIDD (R147E) and on PIDD (zeige PIDD ELISA Kits) (Y814A) exert a dominant negative effect on the formation of the PIDDosome, and that this effect cannot be applied after the PIDDosome has been formed
The expressions of PIDD (zeige PIDD ELISA Kits) and RAIDD are upregulated during tumour progression in renal cell carcinomas.
As a first step towards elucidating the molecular mechanisms of caspase-2 (zeige CASP2 ELISA Kits) activation, data report the crystal structure of the RAIDD death domain at 2.0 A resolution.
PIDD (zeige PIDD ELISA Kits) death domain (DD) and RAIDD DD assemble into an oligomeric complex. Within the PIDDosome, the interaction between PIDD (zeige PIDD ELISA Kits) and RAIDD is mediated by a homotypic interaction between their death domains.
impaired expression of RAIDD in drug induced apoptosis may play a role in the multidrug resistance of osteosarcoma cells
The tumor-modulatory effects of Caspase-2 (zeige CASP2 ELISA Kits) and Pidd1 do not require the scaffold protein (zeige HOMER1 ELISA Kits) Raidd
Neuronal caspase-2 (zeige CASP2 ELISA Kits)-dependent execution of neurons requires recptor-interacting protein RAIDD, not p53-inducible protein with a death domain (PIDD (zeige PIDD ELISA Kits)).
We show that CRADD interacts with BCL10 (zeige BCL10 ELISA Kits) through its caspase (zeige CASP3 ELISA Kits) recruitment domain and suppresses interactions between BCL10 (zeige BCL10 ELISA Kits) and CARMA1 (zeige CARD11 ELISA Kits)
Overexpression of Raidd cDNA in 3T3L1 cells inhibited differentiation of the preadipocytes.
P53-induced protein with a death domain (zeige PIDD ELISA Kits) -induced apoptosis and growth suppression in embryonic fibroblasts depend on the adaptor protein receptor-interacting protein (RIP (zeige RIPK1 ELISA Kits))-associated ICH-1 (zeige CASP2 ELISA Kits)/CED-3 homologous protein with a death domain (RAIDD).
The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.
death domain-containing protein CRADD
, CASP2 and RIPK1 domain containing adaptor with death domain
, Death domain-containing protein CRADD
, death domain-containing protein cradd
, CASP2 and RIPK1 domain containing adaptor with death, gene 2
, RIP-associated ICH1/CED3-homologous protein with death domain
, RIP-associated protein with a death domain
, caspase and RIP adaptor with death domain
, death adaptor molecule RAIDD
, CASP2 and RIPK1 domain-containing adaptor with death domain
, caspase and RIP adapter with death domain