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Coletti, Yang, Marazzi, Sassoon: TNFalpha inhibits skeletal myogenesis through a PW1-dependent pathway by recruitment of caspase pathways. in The EMBO journal 2002
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Doostzadeh-Cizeron, Yin, Goodrich: Apoptosis induced by the nuclear death domain protein p84N5 is associated with caspase-6 and NF-kappa B activation. in The Journal of biological chemistry 2000
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The bactericidal activity of caspase-6-/- macrophages was impaired compared to wild type cells. Caspase-6-/- mice showed higher expression of the IL-1b (zeige IL1B ELISA Kits) gene, known to be detrimental in murine melioidosis. Expression of the IL-10 (zeige IL10 ELISA Kits) gene was also increased in caspase-6-/- mice as early as 6 hours after infection. Treatment with exogenous IL-10 (zeige IL10 ELISA Kits) rendered mice more susceptible against B. pseudomallei challenge
caspase-6 could regulate breast cancer cell invasion by modulating MMP-2 (zeige MMP2 ELISA Kits) and MMP-9 (zeige MMP9 ELISA Kits) expression in 4T1 tumor-associated macrophages
Casp6 is unlikely to be involved in colitis-associated tumors.
p53 (zeige TP53 ELISA Kits) activity is an important upstream regulator of caspase-6 activity in muscle tissue.
TNFalpha (zeige TNF ELISA Kits)-induced RIP1 (zeige RALBP1 ELISA Kits)-independent caspase-6 activation was involved in regulating the relationship between autophagy and necroptosis.
CASP6 released from axonal terminals regulates microglial TNF-alpha (zeige TNF ELISA Kits) secretion, synaptic plasticity, and inflammatory pain.
both Caspase-3 (zeige CASP3 ELISA Kits) and Caspase-6 are implicated in axon degeneration that occurs as a part of normal development.
Casp6-/- neurons are protected against excitotoxicity, nerve growth factor deprivation and myelin-induced axonal degeneration. Furthermore, Casp6-deficient mice show an age-dependent increase in cortical and striatal volume.
This study demonistrated that elimination of caspase-6 protein and activity in the BACHD mouse model does not prevent the production of a 586 aa Htt (zeige HTT ELISA Kits) proteolytic fragment in the brain.
Neutrophil/macrophage contact activates CASP-6, producing interleukin-1 receptor-associated kinase-M (zeige IRAK3 ELISA Kits) (IRAK-M (zeige IRAK3 ELISA Kits)) cleavage and de-repression of alveolar macrophages; CASP-6 deletion protects mice from death caused by bacterial peritonitis.
Results support the possibility that the Casp6 activity in the anterior olfactory nucleus of the olfactory bulb reflects degeneration in the entorhinal cortex and suggest that Casp6 activity in the olfactory bulb could represent degeneration associated with cognitive decline and early Alzheimer disease.
These data suggest that caspase-6 deactivating mutations may contribute to multifactorial carcinogenic transformations.
Caspase-6 undergoes helix-strand transition upon substrate binding. Caspase-6 shows distinctive conformational dynamics in its 130's region Local pKa Values of Key Amino Acid Residues within the 130's Region Vary between the Unliganded (Helical) and the VEID-bound (Strand) States of Caspase-6 .
Following specific binding to and internalization into HER2 (zeige ERBB2 ELISA Kits)-overexpressing tumor cells, the e23sFv-Fdt-casp6 protein induced tumor cell apoptosis and inhibited the proliferation of HER2 (zeige ERBB2 ELISA Kits)-overexpressing A172 and U251MG cells in vitro, but not in U87MG cells with undetectable HER2 (zeige ERBB2 ELISA Kits)
Results identified novel members of the CASP6 interactome and demonstrate that a number of them are involved in key signaling pathways observed in neurodegenerative diseases.
The ability of sox11 (zeige SOX11 ELISA Kits) to reduce effector caspase (zeige CASP3 ELISA Kits) activity was also reflected in its capacity to reduce cell death following toxic insult. Interestingly, other sox (zeige PIPOX ELISA Kits) proteins also had the ability to reduce caspase-6 activity but to a lesser extent than sox11 (zeige SOX11 ELISA Kits)
Caspase-6 plays a role in activating caspase-3 (zeige CASP3 ELISA Kits) in Tau truncation.
unmodified STAT1 (zeige STAT1 ELISA Kits) is cleaved at multiple sites by caspase-3 (zeige CASP3 ELISA Kits) and caspase-6 in malignant undifferentiated hematopoietic cells
p53 (zeige TP53 ELISA Kits) activity is an important upstream regulator of caspase-6 activity in Huntington's disease.
In this study, the crystal structure of a full-length CASP6 zymogen mutant, proCASP6H121A, was solved.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms.
, caspase 6, apoptosis-related cysteine protease
, caspase 6
, apoptotic protease Mch-2
, apoptotic protease MCH-2