anti-Ziege Caspase 3 Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

Subcellular location: Cytoplasm

Synonyms: CPP32, SCA-1, CPP32B, Caspase-3, CASP-3, Apopain, Cysteine protease CPP32, CPP-32, Protein Yama, SREBP cleavage activity 1, CASP3

Zhang, Zhao, Zhang, Hao, Yu, Min, Li, Ma, Chen, Yi, Tang, Meng, Liu, Wang, Shen, Zhang: "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." in: Chemosphere, Vol. 194, pp. 147-157, 2018 Von den Autoren verwendete Methode: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Mouse (Murine)). Weitere Details: Sample: testicular tissue

Abdel-Hamid, El-Azab, Moustafa: "Macrolide antibiotics differentially influence human HepG2 cytotoxicity and modulate intrinsic/extrinsic apoptotic pathways in rat hepatocellular carcinoma model." in: Naunyn-Schmiedeberg's archives of pharmacology, Vol. 390, Issue 4, pp. 379-395, 2017 Von den Autoren verwendete Methode: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Rat (Rattus)). Weitere Details: Sample: liver

Ochigbo, Saba, Oyagbemi, Omobowale, Asenuga: "Polyphenol-rich fraction of Parquetina nigrescens mitigates dichlorvos-induced neurotoxicity and apoptosis." in: Journal of Ayurveda and integrative medicine, Vol. 8, Issue 1, pp. 27-36, 2017 (Probematerial (Species): Rat (Rattus)).

Kubatka, Uramova, Kello, Kajo, Kruzliak, Mojzis, Vybohova, Adamkov, Jasek, Lasabova, Zubor, Fialova, Dokupilova, Solar, Pec, Adamicova, Danko, Adamek, Busselberg: "Antineoplastic effects of clove buds (Syzygium aromaticum L.) in the model of breast carcinoma." in: Journal of cellular and molecular medicine, 2017 Von den Autoren verwendete Methode: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Rat (Rattus)). Weitere Details: Sample: mammary tumour

Wang, Xuan, Cui, Wang, Chen, Wei, Zhao: "Ibutilide treatment protects against ER stress induced apoptosis by regulating calumenin expression in tunicamycin treated cardiomyocytes." in: PLoS ONE, Vol. 12, Issue 4, pp. e0173469, 2017 Von den Autoren verwendete Methode: Western Blotting (WB), Western Blotting (WB) (Probematerial (Species): Rat (Rattus)).

He, Chen, Yuan, Zhao, Chen, Wang, Li: "Tumor pH-Responsive Release of Drug-Conjugated Micelles from Fiber Fragments for Intratumoral Chemotherapy." in: ACS applied materials & interfaces, Vol. 9, Issue 38, pp. 32534-32544, 2017

Li, Shi, Zhao, Li: "Long noncoding RNA CCAT1 functions as a ceRNA to antagonize the effect of miR-410 on the down-regulation of ITPKB in human HCT-116 and HCT-8 cells." in: Oncotarget, Vol. 8, Issue 54, pp. 92855-92863, 2017 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Human).

Clark, Coury, Meilhac, Petty: "WO3/Pt nanoparticles are NADPH oxidase biomimetics that mimic effector cells in vitro and in vivo." in: Nanotechnology, Vol. 27, Issue 6, pp. 65101, 2016

Kubatka, Kello, Kajo, Kruzliak, Výbohová, Mojžiš, Adamkov, Fialová, Veizerová, Zulli, Péč, Statelová, Grančai, Büsselberg: "Oregano demonstrates distinct tumour-suppressive effects in the breast carcinoma model." in: European journal of nutrition, 2016 Von den Autoren verwendete Methode: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Rat (Rattus)).

Yoshinaga, Kajiya, Oishi, Kamada, Ikeda, Chigwechokha, Kibe, Kishida, Kishida, Komatsu, Shiozaki: "NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation." in: European journal of pharmacology, Vol. 782, pp. 21-9, 2016 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Human).

Kassayová, Bobrov, Strojný, Orendáš, Demečková, Jendželovský, Kubatka, Kisková, Kružliak, Adamkov, Bomba, Fedoročko: "Anticancer and Immunomodulatory Effects of Lactobacillus plantarum LS/07, Inulin and Melatonin in NMU-induced Rat Model of Breast Cancer." in: Anticancer research, Vol. 36, Issue 6, pp. 2719-28, 2016 Von den Autoren verwendete Methode: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Rat (Rattus)). Weitere Details: Sample: Mammary

Zhao, Qiu, Tian, Fan: "The cytotoxic and pro-apoptotic effects of phenylephrine on corneal stromal cells via a mitochondrion-dependent pathway both in vitro and in vivo." in: Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, Vol. 68, Issue 7, pp. 409-17, 2016 Von den Autoren verwendete Methode: ELISA (ELISA) (Probematerial (Species): Human).

Chen, He, Chen, Zhao, Li: "Tunable conjugation densities of camptothecin on hyaluronic acid for tumor targeting and reduction-triggered release." in: Acta biomaterialia, Vol. 43, pp. 195-207, 2016 Von den Autoren verwendete Methode: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Mouse (Murine)). Weitere Details: Sample: 4T1 tumor

Zhang, Yu: "Matrine inhibits diethylnitrosamine-induced HCC proliferation in rats through inducing apoptosis via p53, Bax-dependent caspase-3 activation pathway and down-regulating MLCK overexpression." in: Iranian journal of pharmaceutical research : IJPR, Vol. 15, Issue 2, pp. 491-9, 2016 Von den Autoren verwendete Methode: Western Blotting (WB), Western Blotting (WB) (Probematerial (Species): Rat (Rattus)). Weitere Details: Sample: Liver

Huang, Liu, Gong, Wu, Wen: "Expression of DNA methyltransferases and target microRNAs in human tissue samples related to sporadic colorectal cancer." in: Oncology reports, Vol. 36, Issue 5, pp. 2705-2714, 2016 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Mouse (Murine)).

Liu, Su, Hao, Chen, Liu, Liao, Li: "Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice." in: International journal of molecular sciences, Vol. 17, Issue 1, 2016 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Mouse (Murine)). Weitere Details: Sample: testis

Lin, Kuo, Chen, Chien: "Quercetin-Rich Guava (Psidium guajava) Juice in Combination with Trehalose Reduces Autophagy, Apoptosis and Pyroptosis Formation in the Kidney and Pancreas of Type II Diabetic Rats." in: Molecules (Basel, Switzerland), Vol. 21, Issue 3, pp. 334, 2016

Gao, Liu, Li, Wu, Peng, Jing: "Hispidulin induces mitochondrial apoptosis in acute myeloid leukemia cells by targeting extracellular matrix metalloproteinase inducer." in: American journal of translational research, Vol. 8, Issue 2, pp. 1115-32, 2016 Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Human).

Shan, Fan: "Cytotoxicity of carteolol to human corneal epithelial cells by inducing apoptosis via triggering the Bcl-2 family protein-mediated mitochondrial pro-apoptotic pathway." in: Toxicology in vitro : an international journal published in association with BIBRA, Vol. 35, pp. 36-42, 2016 Von den Autoren verwendete Methode: ELISA (ELISA) (Probematerial (Species): Human).

Bozok Cetintas, Acikgoz, Yigitturk, Demir, Oktem, Tezcanli Kaymaz, Oltulu, Aktug: "Effects of flavopiridol on critical regulation pathways of CD133high/CD44high lung cancer stem cells." in: Medicine, Vol. 95, Issue 43, pp. e5150, 2016 Von den Autoren verwendete Methode: Immunofluorescence (fixed cells) (IF/ICC) (Probematerial (Species): Mouse (Murine)).