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Capn4 promotes epithelial-mesenchymal transition in human melanoma cells through activation of the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway.
CAPNS1 depletion is coupled to impairment of breast cancer cell growth.
High levels of Capn4 expression were associated with lymph node metastasis and large tumor size in non-small cell lung cancer patients.Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2 (zeige MMP2 Proteine).
HBXIP (zeige HBXIP Proteine) was able to up-regulate Capn4 at the levels of promoter.
The overexpression of Capn4 is a novel negative prognostic marker, and Capn4 may be used as a new target in therapeutic strategies for human glioma.
Capn4 can contribute to hepatocellular carcinoma growth and metastasis
Capn4 mRNA and protein are increased in human clear cell renal cell carcinoma (zeige MOK Proteine) tissues and higher Capn4 levels are associated with advanced clinical tumour stage and shorter overall survival.
Capn4 upregulated MMP2 (zeige MMP2 Proteine) via nuclear factor-kappaB activation, manifested by increased phosphorylation of p65 (zeige GORASP1 Proteine), a subunit of NF-kappaB (zeige NFKB1 Proteine).
This study suggests that augmented calpain activity is associated with increased incidence of thrombosis under hypoxic environments.
Capn4 overexpression was implicated in ICC metastasis/invasion, and Capn4 overexpression may be used as a molecular therapeutic target for intrahepatic cholangiocarcinoma
A new single nucleotide polymorphism was found in the bovine CAPNS1 gene exon 11 coding for the 3'UTR.
Mitochondrial calpain-1 (zeige CAPN1 Proteine) disrupts ATP synthase, leading to mitochondrial reactive oxygen species generation, which promotes proinflammatory response and myocardial dysfunction during endotoxemia.
Calpain in osteoblasts regulates cell proliferation through its regulation of p27Kip1 (zeige CDKN1B Proteine). Osteoblast-specific capns1 knockout mice developed a high-fat diet-induced excess body weight gain and impaired glucose tolerance.
effects of Capn4 deletion may be mediated through prevention of IkappaB degradation and NF-kappaB (zeige NFKB1 Proteine) activation, resulting in inhibition of inflammatory responses.
Calpain 4 is essential for the tyrosine phosphorylation of galectin-3 (zeige LGALS3 Proteine), and its ultimate secretion from the cell, and its secretion probably interferes with the production of traction forces.
osteoblast-specific Capns1 knockout mice with osteoporosis and reduced bone resorptive function, exhibited reduced serum uncarboxylated osteocalcin (zeige BGLAP Proteine) levels and a lean phenotype under a normal chow diet.
Calpain 4 is not necessary for LFA-1 (zeige ITGAL Proteine)-mediated adhesion, conjugation or migration.
Data suggest that the calpain small subunit, Capn4, is essential for proper chondrocyte functions in embryonic growth plates.
calpain-mediated endoproteolytic cleavage of PrP(Sc) may be an important event in prion (zeige PRNP Proteine) propagation
In calpain-deficient cells, autophagy is impaired with a resulting dramatic increase in apoptotic cell death.
The molecular ordering of PARP-1 (zeige PARP1 Proteine), calpains, Bax (zeige BAX Proteine), and AIF (zeige AIFM1 Proteine) activation is established.
Polymorphisms in PPARGC1A and CAPNS1 genes may affect meat quality traits.
Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene.
calpain, small subunit 1
, CANP small subunit
, calcium-activated neutral proteinase small subunit
, calcium-dependent protease small subunit 1
, calcium-dependent protease, small subunit
, calpain 4, small subunit (30K)
, calpain regulatory subunit
, calpain small subunit 1
, calpain, small polypeptide
, calpain 4
, calpain I light subunit