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High BIRC5 expression is associated with ovarian cancer.
In III-rd trimester of pregnancy parameters of Timp-1 (zeige TIMP1 Proteine) and Survivin - anti-apoptotic substances concentration were similar in maternal and cord blood in both artery and vein. We found no increased activity of selected antiapoptotic factors.
Results form study in non-small-cell lung cancer cells showed that SphK2 (zeige SPHK2 Proteine) plays a critical role in doxorubicin-induced resistance by regulating key anti-apoptotic gene, survivin.
Survivin overexpression plays a key role in the chemoresistance of ovarian CSCs.
Survivin may play an important role in the occurrence and development of laryngeal carcinoma, and its high expression is related to the poor prognosis of patients with laryngeal cancer. (Meta-analysis)
treatment of DLD1 cells with tamoxifen , betaestradiol, or a combination of these two drugs, inhibited cell viability and migration, promoted cell apoptosis, and reduced the mRNA and protein expression levels of survivin in a dose and timedependent manner. These results provide novel experimental basis for hormonal adjuvant therapy for the treatment of colorectal cancers
enigma (zeige PDLIM1 Proteine) siRNA-transfected cells, cell viability, and the protein levels of AKT (zeige AKT1 Proteine) and survivin decreased.
Studies indicated that high survivin expression in renal cell carcinoma (zeige MOK Proteine) (RCC (zeige XRCC1 Proteine)) was associated with poor overall survival [Review].
Nuclear accumulation of survivin is associated with proliferative phenotype and was shown to be a worse prognostic marker in breast ductal carcinoma.
Knockdown of BIRC5, a member of the inhibitor of apoptosis protein (zeige BIRC2 Proteine) family, using either lentiviral vector based CRISPR/Cas9 nickase gene editing or inhibition of survivin using the small-molecule inhibitor YM155, results in the suppression of epithelial to mesenchymal transition in retinal pigment epithelial cells.
Survivin is important for optimal development of bovine blastocysts and confirm that survivin expression suppresses apoptosis of pre-implantation embryos.
Dermatoplasty can decrease spermatogenic cells and reduce Survivin protein expression.
Report survivin expression in the normal pancreas.
The present results indicated that PPARgamma (zeige PPARG Proteine) may serve a protective role on bEnd.3 cells and that BIRC5 may be a downstream target of PPARgamma (zeige PPARG Proteine) regulation during cerebral ischemia.
While induced by exposure to reactive oxygen species generating stresses, the ultimate expression of changes in radiation response is dependent upon the bi-functionality of the tumor associated protein survivin and its intracellular translocation.
HDL (zeige HSD11B1 Proteine)-associated sphingosine 1-phosphate inhibits macrophage apoptosis by stimulating STAT3 (zeige STAT3 Proteine) activity and survivin expression.
Survivin also attenuates DNA damage related to PARP (zeige PARP1 Proteine) activation and inhibits TNFalpha (zeige TNF Proteine)-induced lipolysis, suggesting that Survivin may facilitate adipocyte maintenance in response to inflammatory stimuli.
The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin.
this study shows that that sorafenib promotes the survival of bone marrow cells by up-regulating survivin
Survivin was regulated by TGF-beta (zeige TGFB1 Proteine) and was found to be highly expressed during mucosal healing following intestinal inflammation
Survivin is a key regulator of gut (zeige GUSB Proteine) tissue integrity by regulating epithelial homeostasis in the stem cell niche.
TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt (zeige WNT2 Proteine) in CPCs to mediate cardioprotection and improve cardiac function.
Survivin is a key gene for regulating squamous cell carcinoma (SCC (zeige CYP11A1 Proteine)) cancer stem cell formation and cancer SCC (zeige CYP11A1 Proteine) development.
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
baculoviral IAP repeat-containing 5 (survivin)
, baculoviral IAP repeat-containing protein 5
, baculoviral IAP repeat-containing 5 (survivin)-like
, apoptosis inhibitor survivin
, baculoviral IAP repeat-containing 5
, apoptosis inhibitor 4
, survivin variant 3 alpha