TAB2 Antikörper (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2)

Details for Product anti-TAB2 Antibody No. ABIN969430, Anbieter: Anmelden zum Anzeigen
Antigen
  • CHTD2
  • MAP3K7IP2
  • 1110030N06Rik
  • A530078N03Rik
  • Map3k7ip2
  • mKIAA0733
  • map3k7ip2
  • zgc:77446
  • TGF-beta activated kinase 1/MAP3K7 binding protein 2
  • TAB2
  • Tab2
  • tab2
Reaktivität
Human
62
19
14
7
5
4
3
3
3
2
1
1
1
Wirt
Maus
39
16
10
Klonalität (Klon)
Monoklonal ()
Applikation
Flow Cytometry (FACS), ELISA, Western Blotting (WB)
38
24
20
16
12
8
6
2
2
2
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Immunogen Purified recombinant fragment of human TAB2 expressed in E. Coli.
Klon 3B5
Isotyp IgG1
Reinigung Ascites
Plasmids, Primers & others Plasmide, Primers & weitere TAB2 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung TAB2 (TAB2 Antibody Abstract)
Hintergrund The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.
Molekulargewicht 80 kDa
Gen-ID 23118
HGNC 23118
Pathways T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades
Applikations-hinweise ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C,-20 °C
Informationen zur Lagerung 4°C, -20°C for long term storage
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) antibody (ABIN969430) Figure 1: Flow cytometric analysis of HL-60 cells using TAB2 mouse mAb (green) and ne...
Western Blotting (WB) image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) antibody (ABIN969430) Figure 2: Western blot analysis using TAB2 mAb against HEK293 (1) and TAB2 (AA: 1-300...
Produkt verwendet in: Thienpont, Zhang, Postma, Breckpot, Tranchevent, Van Loo, Møllgård, Tommerup, Bache, Tümer, van Engelen, Menten, Mortier, Waggoner, Gewillig, Moreau, Devriendt, Larsen: "Haploinsufficiency of TAB2 causes congenital heart defects in humans." in: American journal of human genetics, Vol. 86, Issue 6, pp. 839-49, 2010 (PubMed).

Häcker, Karin: "Regulation and function of IKK and IKK-related kinases." in: Science's STKE : signal transduction knowledge environment, Vol. 2006, Issue 357, pp. re13, 2006 (PubMed).

Simmonds, Heward, Carr-Smith, Foxall, Franklyn, Gough: "Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease." in: The Journal of clinical endocrinology and metabolism, Vol. 91, Issue 3, pp. 1056-61, 2006 (PubMed).

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