TAB2 Antikörper (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2)

Details for Product anti-TAB2 Antibody No. ABIN969430, Anbieter: Anmelden zum Anzeigen
Antigen
  • CHTD2
  • MAP3K7IP2
  • 1110030N06Rik
  • A530078N03Rik
  • Map3k7ip2
  • mKIAA0733
  • map3k7ip2
  • zgc:77446
  • TGF-beta activated kinase 1/MAP3K7 binding protein 2
  • TAB2
  • Tab2
  • tab2
Reaktivität
Human
59
17
13
7
6
5
4
4
3
3
2
1
1
1
Wirt
Maus
33
18
10
Klonalität (Klon)
Monoklonal ()
Applikation
Flow Cytometry (FACS), ELISA, Western Blotting (WB)
37
22
16
13
12
6
5
2
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen Purified recombinant fragment of human TAB2 expressed in E. Coli.
Klon 3B5
Isotyp IgG1
Reinigung Ascites
Andere Bezeichnung TAB2 (TAB2 Antibody Abstract)
Hintergrund The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.
Molekulargewicht 80 kDa
Gen-ID 23118
HGNC 23118
Pathways T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades
Applikationshinweise ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C,-20 °C
Informationen zur Lagerung 4°C, -20°C for long term storage
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) antibody (ABIN969430) Figure 1: Flow cytometric analysis of HL-60 cells using TAB2 mouse mAb (green) and ne...
Western Blotting (WB) image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) antibody (ABIN969430) Figure 2: Western blot analysis using TAB2 mAb against HEK293 (1) and TAB2 (AA: 1-300...
Produkt verwendet in: Thienpont, Zhang, Postma, Breckpot, Tranchevent, Van Loo, Møllgård, Tommerup, Bache, Tümer, van Engelen, Menten, Mortier, Waggoner, Gewillig, Moreau, Devriendt, Larsen: "Haploinsufficiency of TAB2 causes congenital heart defects in humans." in: American journal of human genetics, Vol. 86, Issue 6, pp. 839-49, 2010 (PubMed).

Häcker, Karin: "Regulation and function of IKK and IKK-related kinases." in: Science's STKE : signal transduction knowledge environment, Vol. 2006, Issue 357, pp. re13, 2006 (PubMed).

Simmonds, Heward, Carr-Smith, Foxall, Franklyn, Gough: "Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease." in: The Journal of clinical endocrinology and metabolism, Vol. 91, Issue 3, pp. 1056-61, 2006 (PubMed).

Haben Sie etwas anderes gesucht?