LKB1 Antikörper

Produktnummer ABIN969424

Produktdetails anti-LKB1 Antikörper

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Reaktivität: Human, Maus, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LKB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human STK11 expressed in E. coli. ,

Klon: 4H12

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Referenzen für anti-LKB1 Antikörper (ABIN969424)

Al-Nashash, Fatoo, Mirza, Ahmed, Agrawal, Thakor, All: "Spinal cord injury detection and monitoring using spectral coherence." in: IEEE transactions on bio-medical engineering, Vol. 56, Issue 8, pp. 1971-9, (2009) (PubMed).

Shaw: "Tumor suppression by LKB1: SIK-ness prevents metastasis." in: Science signaling, Vol. 2, Issue 86, pp. pe55, (2009) (PubMed).

Cheng, Liu, Wang, Zou, Santiago, Garbitt, Gjoerup, Iglehart, Miron, Richardson, Hahn, Zhao: "SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis." in: Science signaling, Vol. 2, Issue 80, pp. ra35, (2009) (PubMed).

Details zu LKB1

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Andere Bezeichnung: STK11 (STK11 Produkte)

Synonyme: pjs antikoerper, LKB1 antikoerper, XEEK1 antikoerper, Stk11 antikoerper, PJS antikoerper, hLKB1 antikoerper, AA408040 antikoerper, Lkb1 antikoerper, Par-4 antikoerper, R75140 antikoerper, mLKB1 antikoerper, wu:fj61a05 antikoerper, zgc:110180 antikoerper, xeek1 antikoerper, serine/threonine kinase 11 antikoerper, polarization-related protein LKB1 antikoerper, serine/threonine kinase 11 L homeolog antikoerper, STK11 antikoerper, stk11 antikoerper, LOC662493 antikoerper, Stk11 antikoerper, stk11.L antikoerper

Hintergrund:

Description: Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.serine/threonine kinase 11,with two alternatively spliced isoforms,expressed in all tissues,strongly homolog of Xenopus early embryonic kinase 1 (XEEK1),tumor suppressor gene in hamartomas syndrome and in left sided colon carcinogenesis,mutated in sporadic testicular cancer,malignant melanomas and laryngeal tumors,playing a minor role in the development of ovarian carcinoma.LKB1 is a potential target for atherosclerosis and cancer and is shown to be mutated in patients with Peutz-Jeghers cancer syndrome. Tissue specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver.

Aliases: PJS, LKB1, STK11

Molekulargewicht: 54 kDa

Gen-ID: 6794

HGNC: 6794

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effekt