OCT4 Antikörper

Produktnummer ABIN969330

Produktdetails anti-OCT4 Antikörper

Target: OCT4 (POU5F1) (POU Class 5 Homeobox 1 (POU5F1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser OCT4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Immunogen: Synthesized peptide of human Oct4.

Klon: 5F7

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Referenzen für anti-OCT4 Antikörper (ABIN969330)

Zhang, Zhang, Wang, Esteban, Pei: "Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells." in: The Journal of biological chemistry, Vol. 283, Issue 51, pp. 35825-33, (2008) (PubMed).

Cha, Sung, Jung, Kim, Lee, Park: "Epigenetic deregulation of the human Oct4 promoter in mouse cells." in: Development genes and evolution, Vol. 218, Issue 10, pp. 561-6, (2008) (PubMed).

Kaltz, Funari, Hippauf, Delorme, Noël, Riminucci, Jacobs, Häupl, Jorgensen, Charbord, Peschel, Bianco, Oostendorp: "In vivo osteoprogenitor potency of human stromal cells from different tissues does not correlate with expression of POU5F1 or its pseudogenes." in: Stem cells (Dayton, Ohio), Vol. 26, Issue 9, pp. 2419-24, (2008) (PubMed).

Details zu OCT4

Target: OCT4 (POU5F1) (POU Class 5 Homeobox 1 (POU5F1))

Andere Bezeichnung: Oct4 (POU5F1 Produkte)

Synonyme: OCT3 antikoerper, OCT4 antikoerper, OTF-3 antikoerper, OTF3 antikoerper, OTF4 antikoerper, Oct-3 antikoerper, Oct-4 antikoerper, POU5F1 antikoerper, gp9 antikoerper, gp-9 antikoerper, oct4 antikoerper, pou2 antikoerper, POU-2 antikoerper, cb197 antikoerper, spg/pou2 antikoerper, chunp6868 antikoerper, wu:fd18d06 antikoerper, NF-A3 antikoerper, Oct-3/4 antikoerper, Oct3 antikoerper, Oct3/4 antikoerper, Oct4 antikoerper, Otf-3 antikoerper, Otf-4 antikoerper, Otf3 antikoerper, Otf3-rs7 antikoerper, Otf3g antikoerper, Otf4 antikoerper, POU class 5 homeobox 1 antikoerper, POU domain, class 5, transcription factor 3 antikoerper, POU domain, class 5, transcription factor 1 antikoerper, POU5F1 antikoerper, pou5f3 antikoerper, Pou5f1 antikoerper

Hintergrund:

Description: This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6,22)(p21,q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. (provided by RefSeq).Tissue specificity: Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.

Aliases: OCT3, OCT4, OTF3, OTF4, OTF-3, Oct-3, Oct-4, MGC22487, POU5F1

Molekulargewicht: 45 kDa

Gen-ID: 5460

HGNC: 5460

Pathways: Stem Cell Maintenance