IKBKB Antikörper

Produktnummer ABIN969212

Produktdetails anti-IKBKB Antikörper

Target: IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IKBKB Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of IKBKB expressed in E. coli.

Klon: 10A2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Referenzen für anti-IKBKB Antikörper (ABIN969212)

Park, Song, Kim, Son, Lee, Yoon, Kim, Park, Song, Hwang, Jung, Hong: "Cobrotoxin inhibits NF-kappa B activation and target gene expression through reaction with NF-kappa B signal molecules." in: Biochemistry, Vol. 44, Issue 23, pp. 8326-36, (2005) (PubMed).

Kumar, Rajgopal, Pillai, Babu et al.: "Activation of nuclear transcription factor-kappa B is associated with the induction of inhibitory kappa B kinase-beta and involves differential activation of protein kinase C and protein tyrosine ..." in: Neuroscience letters, Vol. 340, Issue 2, pp. 139-42, (2003) (PubMed).

Peet, Li: "IkappaB kinases alpha and beta show a random sequential kinetic mechanism and are inhibited by staurosporine and quercetin." in: The Journal of biological chemistry, Vol. 274, Issue 46, pp. 32655-61, (2000) (PubMed).

Sarin, Lamba, Kumar, Misra, Murthy: "Comparison of endoscopic ligation and propranolol for the primary prevention of variceal bleeding." in: The New England journal of medicine, Vol. 340, Issue 13, pp. 988-93, (1999) (PubMed).

Details zu IKBKB

Target: IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))

Andere Bezeichnung: IKBKB (IKBKB Produkte)

Hintergrund:

Description: IKBKB(Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, also called IKK2/IKKB), is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1.

Aliases: IKBKB

Molekulargewicht: 43 kDa

Gen-ID: 3551

HGNC: 3551

Pathways: NF-kappaB Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteine