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SMARCB1 Antikörper (AA 257-359)

SMARCB1 Reaktivität: Human, Maus, Ratte WB, IF Wirt: Maus Monoclonal 25-BAF47 unconjugated
Produktnummer ABIN968742
  • Target Alle SMARCB1 Antikörper anzeigen
    SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1))
    Bindungsspezifität
    • 16
    • 11
    • 8
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 257-359
    Reaktivität
    • 91
    • 58
    • 27
    • 7
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 80
    • 11
    Maus
    Klonalität
    • 72
    • 19
    Monoklonal
    Konjugat
    • 48
    • 6
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SMARCB1 Antikörper ist unkonjugiert
    Applikation
    • 53
    • 34
    • 15
    • 15
    • 13
    • 13
    • 9
    • 9
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Ratte (Rattus), Human
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse BAF47 aa. 257-359
    Klon
    25-BAF47
    Isotyp
    IgG2a
    Top Product
    Discover our top product SMARCB1 Primärantikörper
  • Kommentare

    Related Products: ABIN968540, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Guidi, Sands, Zambrowicz, Turner, Demers, Webster, Smith, Imbalzano, Jones: "Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice." in: Molecular and cellular biology, Vol. 21, Issue 10, pp. 3598-603, (2001) (PubMed).

    Bruder, Dumanski, Kedra: "The mouse ortholog of the human SMARCB1 gene encodes two splice forms." in: Biochemical and biophysical research communications, Vol. 257, Issue 3, pp. 886-90, (1999) (PubMed).

    Kalpana, Marmon, Wang, Crabtree, Goff: "Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5." in: Science (New York, N.Y.), Vol. 266, Issue 5193, pp. 2002-6, (1995) (PubMed).

  • Target
    SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1))
    Andere Bezeichnung
    BAF47 (SMARCB1 Produkte)
    Synonyme
    SMARCB1 antikoerper, BAF47 antikoerper, INI1 antikoerper, MRD15 antikoerper, RDT antikoerper, RTPS1 antikoerper, SNF5 antikoerper, SNF5L1 antikoerper, Sfh1p antikoerper, Snr1 antikoerper, hSNFS antikoerper, AU020204 antikoerper, Baf47 antikoerper, Ini1 antikoerper, SNF5/INI1 antikoerper, Snf5 antikoerper, fc51b01 antikoerper, smarcb1 antikoerper, wu:fc51b01 antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 S homeolog antikoerper, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b antikoerper, SMARCB1 antikoerper, Smarcb1 antikoerper, smarcb1.S antikoerper, smarcb1b antikoerper
    Hintergrund
    SWI/SNF complexes facilitate gene activation and transcription factor binding by altering repressive chromatin structures in an ATP-dependent manner. In mammals, SWI/SNF complexes are present in mutliple forms that include 9-12 BRG1-associated factors (BAFs) per complex. These BAF proteins range in molecular weight from 47 to 250 kDa. BAF47/SNF5 (SMARCB1/Ini1) complexes with BRG1- and BRM-containing SWI/SNF complexes. BAF47/SNF5 mRNA is widely expressed in cell lines and tissues, and BAF47/SNF5 gene is mutated in many human tumors. The latter is indicative of a tumor suppressor role for BAF47/SNF5. In addition, mice deficient for BAF47 die early in embryogenesis, while BAF47/SNF5 heterozygous mice display a variety of tumors in the soft tissues of the head and neck. BAF47/SNF5 also binds the HIV-1 integrase and stimulates integrase-mediated DNA joining activity. Thus, BAF47/SNF5 is a component of SWI/SNF complexes that may be critical for normal development and tumor suppression, but may also be a protein utilized for viral DNA integration into host DNA. This antibody is routinely tested by western blot analysis.
    Synonyms: SNF5
    Molekulargewicht
    47 kDa
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