SORL1 Antikörper (AA 1220-1337)

Produktnummer ABIN968682

Produktdetails anti-SORL1 Antikörper

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Bindungsspezifität: AA 1220-1337

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SORL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität: Ratte (Rattus), Maus

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human LR11 aa. 1220-1337

Klon: 48-LR11

Isotyp: IgG2a

Anwendungsinformationen

Kommentare:

Related Products: ABIN968545, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-SORL1 Antikörper (ABIN968682)

Doering, Kane, Hsiao, Yao, Shi, Slowik, Dhagat, Scott, Ault, Page-McCaw, Ferland: "Species differences in the expression of Ahi1, a protein implicated in the neurodevelopmental disorder Joubert syndrome, with preferential accumulation to stigmoid bodies." in: The Journal of comparative neurology, Vol. 511, Issue 2, pp. 238-56, (2008) (PubMed).

Posse De Chaves, Vance, Campenot, Kiss, Vance: "Uptake of lipoproteins for axonal growth of sympathetic neurons." in: The Journal of biological chemistry, Vol. 275, Issue 26, pp. 19883-90, (2000) (PubMed).

Jacobsen, Madsen, Moestrup, Lund, Tommerup, Nykjaer, Sottrup-Jensen, Gliemann, Petersen: "Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein." in: The Journal of biological chemistry, Vol. 271, Issue 49, pp. 31379-83, (1997) (PubMed).

Yamazaki, Bujo, Kusunoki, Seimiya, Kanaki, Morisaki, Schneider, Saito: "Elements of neural adhesion molecules and a yeast vacuolar protein sorting receptor are present in a novel mammalian low density lipoprotein receptor family member." in: The Journal of biological chemistry, Vol. 271, Issue 40, pp. 24761-8, (1996) (PubMed).

Details zu SORL1

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Andere Bezeichnung: LR11 (SORL1 Produkte)

Synonyme: SORL1 antikoerper, C11orf32 antikoerper, LR11 antikoerper, LRP9 antikoerper, SORLA antikoerper, SorLA-1 antikoerper, gp250 antikoerper, SorLA antikoerper, 2900010L19Rik antikoerper, AI596264 antikoerper, AW261561 antikoerper, mSorLA antikoerper, Lr11 antikoerper, RGD619914 antikoerper, sortilin related receptor 1 antikoerper, sortilin-related receptor antikoerper, sortilin-related receptor, L(DLR class) A repeats containing antikoerper, sortilin-related receptor, L(DLR class) A repeats-containing antikoerper, sortilin-related receptor, LDLR class A repeats-containing antikoerper, sorl1 antikoerper, LOC582560 antikoerper, SORL1 antikoerper, Sorl1 antikoerper

Hintergrund: The low-density lipoprotein receptor (LDLR) functions in lipoprotein transport pathways, and is involved in familial hypercholesterolemia. Homologues of the LDLR may have diverse functions and their ligands may include biological inactive plasma carrier complexes, plasma lipoproteins, yolk precursors, toxins, and extracellular lipoproteins. LR11 (also known as sorLA-1 and gp250) is a lipoprotein receptor homologue that contains 11 LDL receptor ligand binding repeats (LDLRs), 5 LDL receptor YWTDrepeats, a large fibronectin-type III (FIII) hexarepeat domain similar to neural adhesion proteins, and a domain with similarity to the yeast receptor for vacuolar protein sorting (Vsp10p). LR11mRNA is expressed at high levels in brain, but is also found in liver, pancreas, adrenal gland, and testis. LR11 can bind the ER and Golgi localized receptor associated protein (RAP), which binds to many members of the LDLR family and prevents aggregation of ligands to the LDLRs. In addition, LR11 binds apolipoprotein E-containing lipoproteins. Thus, LR11 is a lipoprotein binding receptor that may have additional functions related to protein sorting and neuronal development.
Synonyms: SorLA, gp250, Lipoprotein Receptor-11

Molekulargewicht: 250 kDa

Pathways: Smooth Muscle Cell Migration