APBA3 Antikörper (AA 63-185)

Produktnummer ABIN968505

Produktdetails anti-APBA3 Antikörper

Target: APBA3 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 3 (APBA3))

Bindungsspezifität: AA 63-185

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser APBA3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), BioImaging (BI)

Kreuzreaktivität: Human

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse Mint3 aa. 63-185

Klon: 32-Mint3

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-APBA3 Antikörper (ABIN968505)

McLoughlin, Irving, Brownlees, Brion, Leroy, Miller: "Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease." in: The European journal of neuroscience, Vol. 11, Issue 6, pp. 1988-94, (1999) (PubMed).

Borg, Straight, Kaech, de Taddéo-Borg, Kroon, Karnak, Turner, Kim, Margolis: "Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting." in: The Journal of biological chemistry, Vol. 273, Issue 48, pp. 31633-6, (1998) (PubMed).

Borg, Yang, De Taddéo-Borg, Margolis, Turner: "The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion." in: The Journal of biological chemistry, Vol. 273, Issue 24, pp. 14761-6, (1998) (PubMed).

Details zu APBA3

Target: APBA3 (Amyloid beta (A4) Precursor Protein-Binding, Family A, Member 3 (APBA3))

Andere Bezeichnung: Mint3 (APBA3 Produkte)

Synonyme: AW208791 antikoerper, Mint-3 antikoerper, X11gamma antikoerper, lin-10 antikoerper, mint3 antikoerper, MGC:15815 antikoerper, X11L2 antikoerper, Mint3 antikoerper, amyloid beta precursor protein binding family A member 3 antikoerper, amyloid beta (A4) precursor protein-binding, family A, member 3 antikoerper, APBA3 antikoerper, Apba3 antikoerper

Hintergrund: Munc18-1-interacting proteins, Mint1, Mint2, and Mint3, are members of the X11 family of proteins, which contain a phosphotyrosine-binding (PTB) domain and two PSD-95-DLG-ZO-1 (PDZ) domains. The PTB domain binds Asn-Pro-X-pTyr, a beta-turn motif found on activated growth factor receptors and other signaling molecules. PDZ domains bind the C-terminus of proteins involved in receptor and channel clustering and protein localization in polarized cells. Both Mint1 and Mint2 are expressed primarily in the nervous system and may interact with Munc18-1 and syntaxin to form a multimeric complex that mediates appropriate docking/fusion of synaptic vesicles. In addition, both Mint1 and Mint2 may be involved in Alzheimer's disease, since Mint2 colocalizes with amyloid precursor protein (APP) and is found in neuritic plaques, while Mint1 can bind APP, and inhibits the processing of APP to the amyloid beta peptide. Mint3 can also bind APP, but differs from Mint1 and Mint2 in its N-terminal region. It is also more widely expressed. Thus, Mint3 may function in signaling pathways, vesicle exocytosis, and/or protein targeting in a wide range of tissues. Mint3 has a calculated molecular weight of 61 kD, but reportedly is observed migrating at 86-89 kD. This antibody is routinely tested by western blot analysis.
Synonyms: X11gamma

Molekulargewicht: 86-89 kDa