TGFB1I1 Antikörper (AA 73-186)

Produktnummer ABIN968400

Produktdetails anti-TGFB1I1 Antikörper

Target: TGFB1I1 (Transforming Growth Factor beta 1 Induced Transcript 1 (TGFB1I1))

Bindungsspezifität: AA 73-186

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TGFB1I1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität: Ratte (Rattus), Human, Hund

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse Hic-5 aa. 73-186

Klon: 34-Hic

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-TGFB1I1 Antikörper (ABIN968400)

Wang, Yang, Guo, Sampson, Hsu, Tsai, Yeh, Wu, Guo, Chang: "Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator." in: The Journal of biological chemistry, Vol. 277, Issue 18, pp. 15426-31, (2002) (PubMed).

Jia, Ransom, Shibanuma, Liu, Welsh, Smoyer: "Identification and characterization of hic-5/ARA55 as an hsp27 binding protein." in: The Journal of biological chemistry, Vol. 276, Issue 43, pp. 39911-8, (2001) (PubMed).

Shibanuma, Mashimo, Kuroki, Nose: "Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence." in: The Journal of biological chemistry, Vol. 269, Issue 43, pp. 26767-74, (1994) (PubMed).

Details zu TGFB1I1

Target: TGFB1I1 (Transforming Growth Factor beta 1 Induced Transcript 1 (TGFB1I1))

Andere Bezeichnung: Hic-5 (TGFB1I1 Produkte)

Synonyme: TGFB1I1 antikoerper, hic5 antikoerper, ara55 antikoerper, hic-5 antikoerper, tsc-5 antikoerper, ARA55 antikoerper, HIC-5 antikoerper, HIC5 antikoerper, TSC-5 antikoerper, Hic5 antikoerper, Ara55 antikoerper, Hic-5 antikoerper, ara-55 antikoerper, transforming growth factor beta 1 induced transcript 1 antikoerper, transforming growth factor beta 1 induced transcript 1 L homeolog antikoerper, TGFB1I1 antikoerper, tgfb1i1 antikoerper, Tgfb1i1 antikoerper, tgfb1i1.L antikoerper

Hintergrund: Focal adhesions are cell structures terminal to the actin-stress fiber bundles. They attach cultured cells to their substratum or extracellular matrix. These adhesions occur through the integrin receptor molecules which link cytoskeletal proteins and extracellular matrix. The intracellular adhesion is composed of a number of proteins such as paxillin, VASP, vinculin, and the focal-adhesion kinases FAK and PYK2/CAKbeta. Hic-5, also described as hydrogen peroxide inducible-mRNA, is a focal adhesion protein that binds to FAK and PYK2. It is ubiquitously expressed with the highest levels found in lung, spleen, and heart. Induction of Hic-5 is accomplished by hydrogen peroxide or TGFbeta1 and is repressed in K-ras transformed cells. Like paxillin, Hic-5 is tyrosine phosphorylated in Src-transformed cells and is highly similar to paxillin in its primary structure. Both proteins contain LIM domains and LD motifs. In addition, Hic-5 localizes to focal adhesions and co-immunoprecipitates with PYK2/CAKbeta in vivo. Thus, Hic-5 may be a substrate for CAKbeta and play a role in signal transduction during proliferation, cell motility, and adhesion.

Molekulargewicht: 50 kDa

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, VEGF Signaling