NUMA1 Antikörper (AA 10-189)

Produktnummer ABIN968038

Produktdetails anti-NUMA1 Antikörper

Target: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Bindungsspezifität: AA 10-189

Reaktivität: Human, Maus, Ratte, Hund, Huhn

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NUMA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Kreuzreaktivität: Maus, Ratte (Rattus), Huhn, Hund

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human NuMA aa. 10-189

Klon: 22-NuMA

Isotyp: IgM

Anwendungsinformationen

Kommentare:

Related Products: ABIN968535, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-NUMA1 Antikörper (ABIN968038)

Elbi, Misteli, Hager: "Recruitment of dioxin receptor to active transcription sites." in: Molecular biology of the cell, Vol. 13, Issue 6, pp. 2001-15, (2002) (PubMed).

Munnia, Schütz, Romeike, Maldener, Glass, Maas, Nastainczyk, Feiden, Fischer, Meese: "Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor." in: Oncogene, Vol. 20, Issue 35, pp. 4853-63, (2001) (PubMed).

Steen, Cubizolles, Le Guellec, Collas: "A kinase-anchoring protein (AKAP)95 recruits human chromosome-associated protein (hCAP)-D2/Eg7 for chromosome condensation in mitotic extract." in: The Journal of cell biology, Vol. 149, Issue 3, pp. 531-6, (2000) (PubMed).

Yang, Lambie, Snyder: "NuMA: an unusually long coiled-coil related protein in the mammalian nucleus." in: The Journal of cell biology, Vol. 116, Issue 6, pp. 1303-17, (1992) (PubMed).

Details zu NUMA1

Target: NUMA1 (Nuclear Mitotic Apparatus Protein 1 (NUMA1))

Andere Bezeichnung: NuMA (NUMA1 Produkte)

Synonyme: NUMA antikoerper, 6720401E04Rik antikoerper, AA764025 antikoerper, AL022610 antikoerper, AU014979 antikoerper, NUMA1 antikoerper, NuMA antikoerper, SP-H antikoerper, numa antikoerper, numa1 antikoerper, nuclear mitotic apparatus protein 1 antikoerper, nuclear mitotic apparatus protein 1 S homeolog antikoerper, NUMA1 antikoerper, Numa1 antikoerper, numa1 antikoerper, numa1.S antikoerper

Hintergrund: NuMA (Nuclear Mitotic Apparatus protein) is a 2115 amino acid protein with a coiled-coil structure similar to that of myosins and intermediate filaments. Indirect immunofluorescence assays indicate that NuMA's localization is very dynamic. During interphase, NuMA is in the nucleus and during mitosis it moves to the polar regions of the mitotic spindle. NuMA is a very abundant phosphoprotein and antibodies to this protein are often found in patients with autoimmune diseases. Although NuMA is thought to be a structural component of the nucleus, the precise cellular function for this protein is still unknown.

Molekulargewicht: 238-290 kDa

Pathways: Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization, M Phase