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TNFRSF4 Antikörper

TNFRSF4 Reaktivität: Maus WB, FACS, IHC (fro) Wirt: Ratte Monoclonal OX-86 unconjugated
Produktnummer ABIN967651
  • Target Alle TNFRSF4 Antikörper anzeigen
    TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))
    Reaktivität
    • 69
    • 52
    • 34
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    Maus
    Wirt
    • 56
    • 38
    • 16
    • 2
    Ratte
    Klonalität
    • 57
    • 53
    Monoklonal
    Konjugat
    • 54
    • 12
    • 11
    • 8
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TNFRSF4 Antikörper ist unkonjugiert
    Applikation
    • 60
    • 53
    • 32
    • 16
    • 14
    • 13
    • 11
    • 11
    • 10
    • 8
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Marke
    BD Pharmingen™
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Recombinant Mouse OX-40 3/4 CD4 Chimeric Protein
    Klon
    OX-86
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product TNFRSF4 Primärantikörper
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4° C.
  • Pippig, Peña-Rossi, Long, Godfrey, Fowell, Reiner, Birkeland, Locksley, Barclay, Killeen: "Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 12, pp. 6520-9, (2000) (PubMed).

    Akiba, Oshima, Takeda, Atsuta, Nakano, Nakajima, Nohara, Yagita, Okumura: "CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 12, pp. 7058-66, (1999) (PubMed).

    Higgins, McDonald, Whittle, Crockett, Shields, MacDonald et al.: "Regulation of T cell activation in vitro and in vivo by targeting the OX40-OX40 ligand interaction: amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 1, pp. 486-93, (1999) (PubMed).

    Weinberg, Vella, Croft: "OX-40: life beyond the effector T cell stage." in: Seminars in immunology, Vol. 10, Issue 6, pp. 471-80, (1999) (PubMed).

    Weinberg, Wegmann, Funatake, Whitham: "Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 3, pp. 1818-26, (1999) (PubMed).

    al-Shamkhani, Birkeland, Puklavec, Brown, James, Barclay: "OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand." in: European journal of immunology, Vol. 26, Issue 8, pp. 1695-9, (1996) (PubMed).

    Stüber, Neurath, Calderhead, Fell, Strober: "Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells." in: Immunity, Vol. 2, Issue 5, pp. 507-21, (1995) (PubMed).

    Baum, Gayle, Ramsdell, Srinivasan, Sorensen, Watson, Seldin, Baker, Sutherland, Clifford: "Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34." in: The EMBO journal, Vol. 13, Issue 17, pp. 3992-4001, (1994) (PubMed).

  • Target
    TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))
    Andere Bezeichnung
    CD134 (TNFRSF4 Produkte)
    Synonyme
    TNFRSF4 antikoerper, ACT35 antikoerper, CD134 antikoerper, Ly-70 antikoerper, Ox40 antikoerper, TXGP1L antikoerper, Txgp1 antikoerper, OX40 antikoerper, TNF receptor superfamily member 4 antikoerper, tumor necrosis factor receptor superfamily, member 4 antikoerper, TNFRSF4 antikoerper, Tnfrsf4 antikoerper
    Hintergrund
    The OX-86 mAb reacts with the OX-40 antigen (CD134), also known as OX-40 receptor, which is a 50-kDa type-I membrane glycoprotein that belongs to the NGFR/TNFR superfamily. Mouse CD134 is expressed on activated CD4+ and CD8+ T lymphocytes and has been shown to be the sole receptor for the OX-40 Ligand (OX-40L). In the brains of mice with actively induced experimental allergic encephalomyelitis, the expression of CD134 on CD4+ T lymphocytes correlates with disease progression. The OX-40/OX-40L system supplies a costimulatory signal for T-cell proliferation and B-cell proliferation and differentiation. In addition, OX-40 antigen provides a costimulatory signal that induces T cells to proliferate in a CD28-independent manner. In the intact animal, CD134 does not appear to be essential for many T-cell responses, but it seems to play a major role in the pathogenesis of some autoimmune diseases. The OX-86 mAb stains both CD4+ and CD8+ activated T cells, and this expression pattern has been confirmed using OX-40L-Ig fusion protein. CD134 was also detected, using OX-86 mAb, on B cells after stimulation with anti-IgM plus anti-CD40 mAb HM40-3. OX-86 mAb does not block binding of OX-40L to OX-40, and it stimulates T-cell proliferation mildly.
    Synonyms: OX-40 Antigen
    Pathways
    Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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