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BCL2L1 Antikörper (AA 3-14)

BCL2L1 Reaktivität: Human, Maus WB Wirt: Maus Monoclonal 2H12 unconjugated
Produktnummer ABIN967301
  • Target Alle BCL2L1 Antikörper anzeigen
    BCL2L1 (BCL2-Like 1 (BCL2L1))
    Bindungsspezifität
    • 28
    • 19
    • 16
    • 16
    • 13
    • 11
    • 11
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 3-14
    Reaktivität
    • 212
    • 131
    • 115
    • 47
    • 25
    • 11
    • 9
    • 7
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    Human, Maus
    Wirt
    • 157
    • 74
    • 2
    Maus
    Klonalität
    • 146
    • 87
    Monoklonal
    Konjugat
    • 124
    • 24
    • 12
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BCL2L1 Antikörper ist unkonjugiert
    Applikation
    • 161
    • 71
    • 62
    • 58
    • 54
    • 33
    • 32
    • 28
    • 28
    • 21
    • 17
    • 10
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Marke
    BD Pharmingen™
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Please refer to us for technical protocols.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human, mouse Bcl-xL / Bcl-xS (aa. 3-14)
    Klon
    2H12
    Isotyp
    IgG2a
    Top Product
    Discover our top product BCL2L1 Primärantikörper
  • Applikationshinweise
    In addition to Jurkat cell lysates, MOLT-4 (Human T-lymphoblasts, ATCC CRL-1582), K-562 (Human bone marrow myelogenous leukemia, ATCC CCL-243), Hut-78 (Human T lymphoma, ATCC TIB-161), human peripheral blood mononuclear cells (PBMC), rat thymocytes and mouse thymocytes have also been reported to be useful as positive controls.
    Kommentare

    Related Products: ABIN968537

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.25 mg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Hsu, Wolter, Youle: "Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 8, pp. 3668-72, (1997) (PubMed).

    Hsu, Youle: "Nonionic detergents induce dimerization among members of the Bcl-2 family." in: The Journal of biological chemistry, Vol. 272, Issue 21, pp. 13829-34, (1997) (PubMed).

    Reed, Miyashita, Krajewski, Takayama, Aime-Sempe, Kitada, Sato, Wang, Harigai, Hanada, Krajewska, Kochel, Millan, Kobayashi: "Bcl-2 family proteins and the regulation of programmed cell death in leukemia and lymphoma." in: Cancer treatment and research, Vol. 84, pp. 31-72, (1996) (PubMed).

    Krajewski, Krajewska, Shabaik, Wang, Irie, Fong, Reed: "Immunohistochemical analysis of in vivo patterns of Bcl-X expression." in: Cancer research, Vol. 54, Issue 21, pp. 5501-7, (1994) (PubMed).

  • Target
    BCL2L1 (BCL2-Like 1 (BCL2L1))
    Andere Bezeichnung
    Bcl-x (BCL2L1 Produkte)
    Synonyme
    BCL-XL/S antikoerper, BCL2L antikoerper, BCLX antikoerper, BCLXL antikoerper, BCLXS antikoerper, Bcl-X antikoerper, PPP1R52 antikoerper, bcl-xL antikoerper, bcl-xS antikoerper, Bcl(X)L antikoerper, Bcl-XL antikoerper, Bcl-Xs antikoerper, Bcl2l antikoerper, BclX antikoerper, bcl-x antikoerper, Bcl-xl antikoerper, Bclx antikoerper, bcl-X antikoerper, Bcl-xL antikoerper, BCL-XL antikoerper, BCL2L1 antikoerper, bcl-XL antikoerper, bcl-x(l) antikoerper, bcl-xl/s antikoerper, bcl-xs antikoerper, bcl2l antikoerper, bclx antikoerper, bclxl antikoerper, xR11 antikoerper, bcl-xl antikoerper, blp1 antikoerper, cb1021 antikoerper, zfBLP1 antikoerper, BCL2 like 1 antikoerper, BCL2-like 1 antikoerper, Bcl2-like 1 antikoerper, BCL2-like 1 L homeolog antikoerper, bcl2-like 1 antikoerper, BCL2L1 antikoerper, Bcl2l1 antikoerper, bcl2l1 antikoerper, bcl2l1.L antikoerper
    Hintergrund
    Members of the Bcl-2 family play a major role in regulating the response of cells to a wide variety of apoptotic signals. Some Bcl-2 family members like Bcl-2, block apoptosis, whereas others promote apoptosis and inhibit Bcl-2 activity. Bcl-x is a Bcl-2 homologue that has two isoforms, resulting from alternative splicing. Bcl-xL (long) is a 241 amino acid protein (25-29 kDa) that is 47% homologous to Bcl-2 on the amino acid level. Bcl-xS (short) is a 178 amino acid protein (~ 19.5 kDa) lacking a 63 amino acid domain that is well conserved among members of the Bcl-2 protein family. Bcl-xL blocks cell death, whereas Bcl-xS inhibits Bcl-2 and promotes cell death. The 2H12 antibody has been reported to recognize human, mouse and rat Bcl-xL (long) protein. An N-terminal peptide (amino acids 3-14) common to human and mouse Bcl-xL and Bcl-xS (short) proteins was used as the immunogen. Thus the antibody is also predicted to recognize the Bcl-xS protein as the sequence used for the immunogen is common to both Bcl-xL and Bcl-xS proteins. Reports from development, however, have indicated that Bcl-xS has not been observable.
    Molekulargewicht
    25-29 kDa
    Pathways
    Apoptose, Negative Regulation of intrinsic apoptotic Signaling
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