SLC39A4 Antikörper (N-Term)

Produktnummer ABIN967275

Produktdetails anti-SLC39A4 Antikörper

Target: SLC39A4 (Solute Carrier Family 39 (Zinc Transporter), Member 4 (SLC39A4))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC39A4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human ZIP4 (Zinc transporter ZIP4)

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C

Referenzen für anti-SLC39A4 Antikörper (ABIN967275)

Kim, Wang, Dufner-Beattie, Andrews, Eide, Petris: "Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane." in: The Journal of biological chemistry, Vol. 279, Issue 6, pp. 4523-30, (2004) (PubMed).

Küry, Dréno, Bézieau, Giraudet, Kharfi, Kamoun, Moisan: "Identification of SLC39A4, a gene involved in acrodermatitis enteropathica." in: Nature genetics, Vol. 31, Issue 3, pp. 239-40, (2002) (PubMed).

Wang, Zhou, Kuo, Zemansky, Gitschier: "A novel member of a zinc transporter family is defective in acrodermatitis enteropathica." in: American journal of human genetics, Vol. 71, Issue 1, pp. 66-73, (2002) (PubMed).

Details zu SLC39A4

Target: SLC39A4 (Solute Carrier Family 39 (Zinc Transporter), Member 4 (SLC39A4))

Andere Bezeichnung: ZIP4 (SLC39A4 Produkte)

Synonyme: AEZ antikoerper, AWMS2 antikoerper, ZIP4 antikoerper, 1600025H15Rik antikoerper, AU041686 antikoerper, solute carrier family 39 member 4 antikoerper, solute carrier family 39 (zinc transporter), member 4 antikoerper, SLC39A4 antikoerper, slc39a4 antikoerper, Slc39a4 antikoerper

Hintergrund: ZIP4 (Zinc transporter ZIP4) plays an important role in cellular zinc homeostasis as a zinc transporter. ZIP4 is regulated in response to zinc availability. ZIP4 is a multi-pass membrane protein and is colocalized with TFRC in the recycling endosomes. ZIP4 cycles between endosomal compartments and the plasma membrane in response to zinc availability. ZIP4 is highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum. Defects in SLC39A4 are the cause of acrodermatitis enteropathica zinc-deficiency type (AEZ). AEZ is a rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinicals features are growth retardation, immune system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. All these manifestations are reversible with zinc supplementation. Without zinc therapy this disease is fatal. ZIP4 belongs to the ZIP transporter (TC 2.A.5) family.
Synonyms: SLC39A4 (Solute carrier family 39 member 4), ZIP-4 (Zrt- and Irt-like protein 4)

Pathways: Transition Metal Ion Homeostasis, Autophagie