TRIM5 Antikörper (Tripartite Motif Containing 5)

Details for Product anti-TRIM5 Antibody No. ABIN967208, Anbieter: Anmelden zum Anzeigen
Antigen
  • TRIM5
  • RNF88
  • TRIM5alpha
  • EG667823
  • Gm8833
  • RGD1304579
  • tripartite motif containing 5
  • tripartite motif-containing 5
  • TRIM5
  • Trim5
Reaktivität
Human
144
7
5
1
1
1
Wirt
96
38
13
Klonalität
Monoklonal
Konjugat
Dieser TRIM5 Antikörper ist unkonjugiert
5
5
5
4
4
4
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
123
102
68
37
12
7
6
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Isotyp IgG1
Spezifität Ni-NTA purified truncated recombinant human trim5 alpha expressed in E. Coli strain BL21 (DE3)
Reinigung Crude ascites.
Plasmids, Primers & others Plasmide, Primers & weitere TRIM5 products on genomics-online (e.g. as negative or positive controls)
Andere Bezeichnung Trim5a (TRIM5 Antibody Abstract)
Hintergrund TRIM5-alpha is a protein that is found in the cells of many mammals and fends of various retrovirus infections. It protects monkeys from infection with HIV-1, and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5 alpha, which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.
Pathways Activation of Innate immune Response
Applikations-hinweise Western Blot: Dilution 1: 1,000- 1: 5,000
IHC(P): Dilution 1: 100- 1: 400
IHC(F): Dilution 1: 200- 1: 400 Determining optimal working dilutions by titration test.
Beschränkungen Nur für Forschungszwecke einsetzbar
Lagerung -20 °C
Produkt verwendet in: Song, Javanbakht, Perron, Park, Stremlau, Sodroski: "Retrovirus restriction by TRIM5alpha variants from Old World and New World primates." in: Journal of virology, Vol. 79, Issue 7, pp. 3930-7, 2005 (PubMed).

Stremlau, Owens, Perron, Kiessling, Autissier, Sodroski: "The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys." in: Nature, Vol. 427, Issue 6977, pp. 848-53, 2004 (PubMed).

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