P-Cadherin Antikörper (AA 612-626)

Produktnummer ABIN966724

Produktdetails anti-P-Cadherin Antikörper

Target: P-Cadherin (CDH3)

Bindungsspezifität: AA 612-626

Reaktivität: Human

Wirt: Bitte anfragen

Klonalität: Polyklonal

Konjugat: Dieser P-Cadherin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Immunogen: A synthetic peptide corresponding to a sequence at the middle region of human P-Cadherin (612-626 aa), different from the mouse and rat sequence by one amino acid.

Anwendungsinformationen

Applikationshinweise: WB: The detection limit for P-Cadherin is approximately 2.5ng/lane under non-reducing and reducing conditions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Lagerung: -20 °C

Referenzen für anti-P-Cadherin Antikörper (ABIN966724)

Kaupmann, Becker-Follmann, Scherer, Jockusch, Starzinski-Powitz: "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species." in: Genomics, Vol. 14, Issue 2, pp. 488-90, (1992) (PubMed).

Details zu P-Cadherin

Target: P-Cadherin (CDH3)

Andere Bezeichnung: P-Cadherin (CDH3 Produkte)

Synonyme: CDH3 antikoerper, Cadherin-3 antikoerper, AI385538 antikoerper, Cadp antikoerper, Cdhp antikoerper, P-cadherin antikoerper, Pcad antikoerper, CDHP antikoerper, HJMD antikoerper, PCAD antikoerper, E-Cad antikoerper, E-cadherin antikoerper, EP-cadherin antikoerper, XTCAD-1 antikoerper, c-cadherin antikoerper, cadherin-1 antikoerper, cdh1 antikoerper, cdh1-b antikoerper, cdh3 antikoerper, cdhc-A antikoerper, cdhp antikoerper, hjmd antikoerper, l-cam antikoerper, lcam antikoerper, pcad antikoerper, uvo antikoerper, uvomorulin antikoerper, xb-cad antikoerper, xcdh1 antikoerper, CDH15 antikoerper, K-CAM antikoerper, cadherin 3 antikoerper, cadherin 3 L homeolog antikoerper, Cadherin-3 antikoerper, CDH3 antikoerper, Cdh3 antikoerper, cdh3.L antikoerper, cdh-3 antikoerper

Hintergrund: Cadherins, such as CDH3, are integral membrane glycoproteins responsible for calcium-dependent cell-cell adhesion. Cadherin-3 is a protein that in humans is encoded by the CDH3 gene. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.