FOXD3 Antikörper

Produktnummer ABIN966161

Produktdetails anti-FOXD3 Antikörper

Target: FOXD3 (Forkhead Box D3 (FOXD3))

Reaktivität: Human, Maus, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FOXD3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human FOXD3 expressed in E. Coli.

Klon: 5G9

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-FOXD3 Antikörper (ABIN966161)

Saleem, Banerjee-Basu, Berry, Baxevanis, Walter: "Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1." in: American journal of human genetics, Vol. 68, Issue 3, pp. 627-41, (2001) (PubMed).

Hromas, Moore, Johnston, Socha, Klemsz: "Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells." in: Blood, Vol. 81, Issue 11, pp. 2854-9, (1993) (PubMed).

Details zu FOXD3

Target: FOXD3 (Forkhead Box D3 (FOXD3))

Andere Bezeichnung: FOXD3 (FOXD3 Produkte)

Synonyme: AIS1 antikoerper, Genesis antikoerper, HFH2 antikoerper, VAMAS2 antikoerper, CWH3 antikoerper, Hfh2 antikoerper, fkd6 antikoerper, fkh6 antikoerper, forkhead-6 antikoerper, zgc:111934 antikoerper, XFD-6 antikoerper, xfoxd3 antikoerper, FOXD3 antikoerper, genesis antikoerper, hfh2 antikoerper, foxd3b antikoerper, foxd3b-A antikoerper, forkhead box D3 antikoerper, forkhead box D3 L homeolog antikoerper, forkhead box D3 S homeolog antikoerper, FOXD3 antikoerper, Foxd3 antikoerper, foxd3 antikoerper, foxd3.L antikoerper, foxd3.S antikoerper

Hintergrund: FoxD3 is a member of the Forkhead Box family and is characterized by a winged-helix DNA-binding structure and the important role it plays in embryonic development . This transcriptional regulator is required for the maintenance of pluripotency in the pre-implantation and peri-implantation stages of mouse embryonic development and is also required for trophoblast formation . FoxD3 is required for the maintenance of the mammalian neural crest, FoxD3(-/-) mouse embryos fail around the time of implantation with loss of neural crest-derived structures . FoxD3 also forms a regulatory network with Oct-4 and NANOG to maintain the pluripotency of ES cells. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis .
Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined .
Synonyms: AIS1, HFH2, Genesis, FOXD3

Molekulargewicht: 48kDa

Gen-ID: 27022