FGFR4 Antikörper (Extracellular)

Produktnummer ABIN966141

Produktdetails anti-FGFR4 Antikörper

Target: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Bindungsspezifität: Extracellular

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FGFR4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant extracellular fragment of human FGFR4 fused with hIgGFc tag expressed in HEK293 cell line.

Klon: 7H1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Bloting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-FGFR4 Antikörper (ABIN966141)

Streit, Mestel, Schmidt, Ullrich, Berking: "FGFR4 Arg388 allele correlates with tumour thickness and FGFR4 protein expression with survival of melanoma patients." in: British journal of cancer, Vol. 94, Issue 12, pp. 1879-86, (2006) (PubMed).

Details zu FGFR4

Target: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Andere Bezeichnung: FGFR4 (FGFR4 Produkte)

Synonyme: FGFR4 antikoerper, XFGFR-4 antikoerper, XFGFR-4a antikoerper, cd334 antikoerper, fgfr-4 antikoerper, jtk2 antikoerper, tkf antikoerper, xfgfr4 antikoerper, CD334 antikoerper, JTK2 antikoerper, TKF antikoerper, Fgfr-4 antikoerper, etID309818.21 antikoerper, wu:fc13h10 antikoerper, zgc:111935 antikoerper, fgfr-4c antikoerper, fgfr4 antikoerper, fibroblast growth factor receptor 4 antikoerper, fibroblast growth factor receptor 4 S homeolog antikoerper, FGFR4 antikoerper, fgfr4 antikoerper, Fgfr4 antikoerper, fgfr4.S antikoerper

Hintergrund: FGFR4: fibroblast growth factor receptor 4. Entrez Protein NP_002002. It is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
Synonyms: TKF, JTK2, CD334

Molekulargewicht: 87.9kDa

Gen-ID: 811

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Growth Factor Binding