FCER2 Antikörper

Produktnummer ABIN966132

Produktdetails anti-FCER2 Antikörper

Target: FCER2 (Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FCER2 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human FCER2 expressed in E. Coli.

Klon: 5B5

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-FCER2 Antikörper (ABIN966132)

Bertram: "Fluid flow in distensible vessels." in: Clinical and experimental pharmacology & physiology, Vol. 36, Issue 2, pp. 206-16, (2009) (PubMed).

Shen, Vermeulen, Rajaraman, Menashe, He, Chapman, Yeager, Thomas, Burdett, Hutchinson, Yuenger, Chanock, Lan: "Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China." in: Environmental and molecular mutagenesis, Vol. 50, Issue 4, pp. 285-90, (2009) (PubMed).

Carvalho, Fullen, Lowe, Su, Ma: "Comparison of CD23 staining patterns in Merkel cell carcinoma and non-cutaneous small cell carcinoma." in: Journal of cutaneous pathology, Vol. 36, Issue 2, pp. 206-10, (2009) (PubMed).

Details zu FCER2

Target: FCER2 (Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2))

Andere Bezeichnung: FCER2 (FCER2 Produkte)

Synonyme: BLAST-2 antikoerper, CD23 antikoerper, CD23A antikoerper, CLEC4J antikoerper, FCE2 antikoerper, IGEBF antikoerper, Fcer2a antikoerper, Fc fragment of IgE receptor II antikoerper, FCER2 antikoerper, Fcer2 antikoerper

Hintergrund: The human leukocyte differentiation antigen CD23 (FCE2) is a key molecule for B-cell activation and growth. It is the low-affinity receptor for IgE. The truncated molecule can be secreted, then functioning as a potent mitogenic growth factor.(supplied by OMIM) . It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a membrane bound cytokine, in that the soluble cleavage products of CD23 are themselves able to act as cytokines in vitro.
Synonyms: CD23, FCE2, CD23A, IGEBF, CLEC4J, FCER2

Molekulargewicht: 37kDa

Gen-ID: 2208

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process