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E-cadherin Antikörper

CDH1 Reaktivität: Human, Maus, Affe WB, IHC, FACS, ELISA Wirt: Maus Monoclonal 7A2 unconjugated
Produktnummer ABIN965839
  • Target Alle E-cadherin (CDH1) Antikörper anzeigen
    E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
    Reaktivität
    • 251
    • 103
    • 87
    • 18
    • 17
    • 16
    • 9
    • 9
    • 9
    • 6
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Affe
    Wirt
    • 202
    • 83
    • 8
    • 7
    Maus
    Klonalität
    • 188
    • 111
    • 1
    Monoklonal
    Konjugat
    • 141
    • 36
    • 29
    • 10
    • 10
    • 9
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser E-cadherin Antikörper ist unkonjugiert
    Applikation
    • 207
    • 94
    • 92
    • 68
    • 57
    • 56
    • 39
    • 35
    • 29
    • 27
    • 17
    • 16
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), ELISA
    Aufreinigung
    Ascitic fluid
    Immunogen
    Purified recombinant fragment of human CDH1 expressed in E. Coli.
    Klon
    7A2
    Isotyp
    IgG1
    Top Product
    Discover our top product CDH1 Primärantikörper
  • Applikationshinweise
    Western Bloting: 1/500 - 1/2000.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
  • Schietke, Warnecke, Wacker, Schödel, Mole, Campean, Amann, Goppelt-Struebe, Behrens, Eckardt, Wiesener: "The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1." in: The Journal of biological chemistry, Vol. 285, Issue 9, pp. 6658-69, (2010) (PubMed).

    Barrett, Lee, Lees, Prescott, Anderson, Phillips, Wesley, Parnell, Zhang, Drummond, Nimmo, Massey, Blaszczyk, Elliott, Cotterill, Dallal, Lobo, Mowat, Sanderson, Jewell, Newman, Edwards, Ahmad et al.: "Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. ..." in: Nature genetics, Vol. 41, Issue 12, pp. 1330-4, (2009) (PubMed).

    Rigby: "Statistical reviewing for disability and rehabilitation." in: Disability and rehabilitation, Vol. 31, Issue 7, pp. 515-21, (2009) (PubMed).

  • Target
    E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
    Andere Bezeichnung
    CDH1 (CDH1 Produkte)
    Synonyme
    Arc-1 antikoerper, CD324 antikoerper, CDHE antikoerper, ECAD antikoerper, LCAM antikoerper, UVO antikoerper, E-cadherin antikoerper, cdh1 antikoerper, si:dz180o5.2 antikoerper, uvo antikoerper, lcam antikoerper, E-Cad antikoerper, XBcad antikoerper, l-cam antikoerper, xcdh1 antikoerper, cdhc-A antikoerper, xb-cad antikoerper, XTCAD-1 antikoerper, c-cadherin antikoerper, cadherin-1 antikoerper, uvomorulin antikoerper, XB-cadherin antikoerper, arc-1 antikoerper, cd324 antikoerper, cdhe antikoerper, ecad antikoerper, AA960649 antikoerper, E-cad antikoerper, Ecad antikoerper, L-CAM antikoerper, Um antikoerper, cadherin 1 antikoerper, si:busm1-180o5.2 antikoerper, cadherin 1, type 1, E-cadherin (epithelial) antikoerper, cadherin 1, type 1 S homeolog antikoerper, CDH1 antikoerper, si:busm1-180o5.2 antikoerper, cdh1 antikoerper, Cdh1 antikoerper, cdh1.S antikoerper
    Hintergrund
    E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calciumdependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.
    Tissue specificity: Non-neural epithelial tissues.
    Synonyms: UVO, CDHE, ECAD, LCAM, Arc-1, CD324, CDH1
    Molekulargewicht
    135kDa
    Gen-ID
    999
    Pathways
    WNT Signalweg, Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation
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