RECQL2 Antikörper (Middle Region, Thr802)

Produktnummer ABIN955584

Produktdetails anti-RECQL2 Antikörper

Target: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Bindungsspezifität: AA 794-825, Middle Region, Thr802

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RECQL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects WRN (Center).

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein A column; followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 794-825 (T802 amino acids from the Central region of human WRN

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

Details zu RECQL2

Target: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Andere Bezeichnung: WRN (WRN Produkte)

Synonyme: RECQ3 antikoerper, RECQL2 antikoerper, RECQL3 antikoerper, xBLM antikoerper, recq2 antikoerper, recql2 antikoerper, recql3 antikoerper, AI846146 antikoerper, ffa-1 antikoerper, xwrn antikoerper, RGD1564788 antikoerper, Werner syndrome RecQ like helicase antikoerper, mediator of RNA polymerase II transcription subunit 34 antikoerper, Bloom syndrome RecQ like helicase antikoerper, Werner syndrome, RecQ helicase-like L homeolog antikoerper, WRN antikoerper, LOC9327212 antikoerper, blm antikoerper, Wrn antikoerper, wrn.L antikoerper

Hintergrund: This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.Synonyms: DNA helicase, Exonuclease WRN, RECQ3, RECQL2, RecQ protein-like 2, RecQ-like type 3, RecQ3, Werner syndrome ATP-dependent helicase

Gen-ID: 7486

NCBI Accession: NP_000544

Pathways: DNA Reparatur