RASGRP2 Antikörper (N-Term)

Produktnummer ABIN954463

Produktdetails anti-RASGRP2 Antikörper

Target: RASGRP2 (RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2))

Bindungsspezifität: AA 14-42, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RASGRP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody recognizes Human RASGRP2 (N-term).

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat and Bovine.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of Human RASGRP2. Genename: RASGRP2

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-RASGRP2 Antikörper (ABIN954463)

Lima, Parreira, Devuyst, Caplanusi, Nkuli, Marien, Van Der Smissen, Alves, Verroust, Christensen, Terzi, Matter, Balda, Pierreux, Courtoy: "ZONAB promotes proliferation and represses differentiation of proximal tubule epithelial cells." in: Journal of the American Society of Nephrology : JASN, Vol. 21, Issue 3, pp. 478-88, (2010) (PubMed).

Katagiri, Shimonaka, Kinashi: "Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1." in: The Journal of biological chemistry, Vol. 279, Issue 12, pp. 11875-81, (2004) (PubMed).

Eto, Murphy, Kerrigan, Bertoni, Stuhlmann, Nakano, Leavitt, Shattil: "Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 20, pp. 12819-24, (2002) (PubMed).

Guo, Kumahara, Saffen: "A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2." in: The Journal of biological chemistry, Vol. 276, Issue 27, pp. 25568-81, (2001) (PubMed).

Toki, Kawasaki, Tashiro, Housman, Graybiel: "Guanine nucleotide exchange factors CalDAG-GEFI and CalDAG-GEFII are colocalized in striatal projection neurons." in: The Journal of comparative neurology, Vol. 437, Issue 4, pp. 398-407, (2001) (PubMed).

Details zu RASGRP2

Target: RASGRP2 (RAS Guanyl Releasing Protein 2 (Calcium and DAG-Regulated) (RASGRP2))

Andere Bezeichnung: RASGRP2 (RASGRP2 Produkte)

Synonyme: CALDAG-GEFI antikoerper, CDC25L antikoerper, xrasgrp2 antikoerper, RASGRP2 antikoerper, Caldaggef1 antikoerper, CalDAG-GEFI antikoerper, rasgrp2 antikoerper, RAS guanyl releasing protein 2 antikoerper, RAS guanyl releasing protein 2 (calcium and DAG-regulated) S homeolog antikoerper, RAS, guanyl releasing protein 2 antikoerper, RAS guanyl releasing protein 2 (calcium and DAG-regulated) L homeolog antikoerper, RASGRP2 antikoerper, rasgrp2.S antikoerper, Rasgrp2 antikoerper, rasgrp2.L antikoerper

Hintergrund: The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Three alternatively spliced transcript variants encoding the same protein have been found for this gene.Synonyms: CDC25L, CalDAG-GEFI, Calcium and DAG-regulated guanine nucleotide exchange factor I, Cdc25-like protein, MCG7, RAS guanyl-releasing protein 2

Molekulargewicht: 75kd

Gen-ID: 10235

NCBI Accession: NP_001092140

Pathways: T-Zell Rezeptor Signalweg