HLA-DQA1 Antikörper (Middle Region)

Produktnummer ABIN952750

Produktdetails anti-HLA-DQA1 Antikörper

Target: HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ alpha 1 (HLA-DQA1))

Bindungsspezifität: AA 56-84, Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HLA-DQA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Spezifität: This antibody recognizes Human HLA class II DQ alpha 1 / HLA-DQA1 (Center).

Aufreinigung: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 56-84 amino acids from the Central region of Human HLA class II DQ alpha 1 / HLA-DQA1

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu HLA-DQA1

Target: HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ alpha 1 (HLA-DQA1))

Abstract: HLA-DQA1 Produkte

Synonyme: CD antikoerper, CELIAC1 antikoerper, DQ-A1 antikoerper, GSE antikoerper, HLA-DQA antikoerper, BoLA-DQA antikoerper, hla-dqa1 antikoerper, major histocompatibility complex, class II, DQ alpha 1 antikoerper, major histocompatibility complex, class II, DQ alpha, type 1 antikoerper, major histocompatibility complex, class II, DQ alpha 1 L homeolog antikoerper, HLA-DQA1 antikoerper, BOLA-DQA1 antikoerper, hla-dqa1.L antikoerper

Hintergrund: HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.Synonyms: DC-1 alpha chain, DC-alpha, HLA class II histocompatibility antigen DQ(3) alpha chain, HLA-DCA, MHC class II DQA1

Molekulargewicht: 27805 Da

Gen-ID: 100133678

NCBI Accession: NP_002113

Pathways: T-Zell Rezeptor Signalweg, Cancer Immune Checkpoints