HLA B7 Antikörper (Middle Region)

Produktnummer ABIN952748

Produktdetails anti-HLA B7 Antikörper

Target: HLA B7 (HLA Class I B7 Alpha (HLA B7))

Bindungsspezifität: AA 184-212, Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HLA B7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody recognizes Human HLA class I B7 alpha / HLA-B (Center).

Aufreinigung: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 184-212 amino acids from the Central region of human HLA-B

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu HLA B7

Target: HLA B7 (HLA Class I B7 Alpha (HLA B7))

Abstract: HLA B7 Produkte

Synonyme: AS antikoerper, HLAB antikoerper, SPDA1 antikoerper, major histocompatibility complex, class I, B antikoerper, HLA-B antikoerper

Hintergrund: HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.Synonyms: B-7 alpha chain, HLA class I histocompatibility antigen, HLAB, MHC class I antigen B7

Molekulargewicht: 40460 Da

Gen-ID: 3106

NCBI Accession: NP_005505