CPSF4 Antikörper (Middle Region)

Produktnummer ABIN951684

Produktdetails anti-CPSF4 Antikörper

Target: CPSF4 (Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4))

Bindungsspezifität: AA 102-132, Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CPSF4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody recognizes Human CPSF4 (Center).

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 102~132 amino acids from the Central region of Human CPSF4. Genename: CPSF4

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CPSF4

Target: CPSF4 (Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4))

Andere Bezeichnung: CPSF4 (CPSF4 Produkte)

Synonyme: cpsf30 antikoerper, nar antikoerper, neb1 antikoerper, 30kDa antikoerper, C79664 antikoerper, CPSF30 antikoerper, NAR antikoerper, NEB1 antikoerper, cleavage and polyadenylation specific factor 4 antikoerper, cleavage and polyadenylation specific factor 4, 30kDa antikoerper, cleavage and polyadenylation specific factor 4 S homeolog antikoerper, CPSF4 antikoerper, Cpsf4 antikoerper, LOC733099 antikoerper, LOC100360200 antikoerper, cpsf4.S antikoerper, cpsf4 antikoerper

Hintergrund: Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs.Synonyms: CPSF30, Cleavage and polyadenylation specificity factor 30 kDa subunit, Cleavage and polyadenylation specificity factor subunit 4, NAR, NEB1, NS1 effector domain-binding protein 1, No arches homolog

Molekulargewicht: 30255 Da

Gen-ID: 10898

NCBI Accession: NP_001075028