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STAT1 Antikörper (pSer727)

STAT1 Reaktivität: Human WB, IP Wirt: Maus Monoclonal PSM1 unconjugated
Produktnummer ABIN94473
  • Target Alle STAT1 Antikörper anzeigen
    STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))
    Bindungsspezifität
    • 53
    • 47
    • 16
    • 15
    • 13
    • 7
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer727
    Reaktivität
    • 208
    • 121
    • 83
    • 24
    • 18
    • 16
    • 15
    • 13
    • 11
    • 10
    • 7
    • 7
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    Human
    Wirt
    • 188
    • 38
    • 2
    Maus
    Klonalität
    • 165
    • 63
    Monoklonal
    Konjugat
    • 125
    • 11
    • 11
    • 9
    • 8
    • 8
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Dieser STAT1 Antikörper ist unkonjugiert
    Applikation
    • 149
    • 67
    • 54
    • 54
    • 39
    • 32
    • 27
    • 26
    • 26
    • 12
    • 8
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunoprecipitation (IP)
    Spezifität
    The antibody PSM1 recognizes transcriptional factor STAT1 (91 kDa) activated by phosphorylation at Ser727 (intracellular antigen).
    Kreuzreaktivität (Details)
    Other not tested, Human
    Aufreinigung
    Purified by protein-A affinity chromatography.
    Reinheit
    > 95 % (by SDS-PAGE)
    Immunogen
    STAT1 peptide sequence 721-733 (Ser727 phosphorylated).
    Klon
    PSM1
    Isotyp
    IgG1
    Top Product
    Discover our top product STAT1 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze.
  • Kovarik, Boudny, Kocak, Lauerova, Fait, Vagundova: "Malignant melanoma associates with deficient IFN-induced STAT 1 phosphorylation." in: International journal of molecular medicine, Vol. 12, Issue 3, pp. 335-40, (2003) (PubMed).

    Boudný, Kocák, Lauerová, Kovarík: "Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients." in: Folia biologica, Vol. 49, Issue 4, pp. 142-6, (2003) (PubMed).

  • Target
    STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))
    Andere Bezeichnung
    STAT1 (STAT1 Produkte)
    Synonyme
    CANDF7 antikoerper, ISGF-3 antikoerper, STAT91 antikoerper, 2010005J02Rik antikoerper, AA408197 antikoerper, XStat1 antikoerper, STAT4 antikoerper, DD6G4-4 antikoerper, STAT antikoerper, STAT1 antikoerper, dZ182H3.3 antikoerper, si:by134g18.2 antikoerper, si:by51f19.1 antikoerper, si:dz182h3.3 antikoerper, si:dz199m19.1 antikoerper, si:dz73o4.2 antikoerper, stat1 antikoerper, signal transducer and activator of transcription 1 antikoerper, signal transducer and activator of transcription 1 L homeolog antikoerper, signal transducer and activator of transcription 1, 91kDa antikoerper, signal transducer and activator of transcription 4 antikoerper, signal transducer and activator of transcription 1a antikoerper, STAT1 antikoerper, Stat1 antikoerper, stat1.L antikoerper, stat4 antikoerper, stat1a antikoerper
    Hintergrund
    Signal transducer and activator of transcription 1,STAT1 (signal transducer and activator of transcription 1) is a transcription factor that plays important roles in growth arrest, apoptosis promoting and tumour suppression. After ligation of cytokine receptors STAT1 becomes phosphorylated on Tyr701 by Janus kinase JAK1 or JAK2, dimerizes, translocates to nucleus and contacts DNA. STAT1-STAT2 heterodimers serve as more potent transcriptional inducers than STAT1 homodimers. STAT1 is also phosphorylated on Ser727 by MAPK pathway, independently of tyrosine phosphorylation. However, the both modifications are important for its maximal transcriptional activity. On the other hand, STAT1 phosphorylated on Ser727 is targeted for proteasomal degradation.,CANDF7, IMD31, ISGF3
    Gen-ID
    6772
    UniProt
    P42224
    Pathways
    JAK-STAT Signalweg, RTK Signalweg, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events
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