LAT Antikörper (Linker For Activation of T Cells)

Details for Product anti-LAT Antibody No. ABIN94420, Anbieter: Anmelden zum Anzeigen
Antigen
  • LAT
  • lat
  • LAT1
  • pp36
  • linker for activation of T-cells
  • linker for activation of T cells
  • LAT
  • lat
  • Lat
Reaktivität
Maus, Ratte (Rattus)
277
121
102
3
2
1
Wirt
Maus
168
102
12
2
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser LAT Antikörper ist unkonjugiert
9
9
8
7
7
6
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
1
1
Applikation
Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blotting (WB)
212
80
51
50
39
33
31
9
6
3
2
2
1
1
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Bacterially expressed full-length rat LAT
Klon LAT-1D1
Isotyp IgG2a
Spezifität The antibody LAT-1D1 reacts with mouse and rat Linker for activation of T cells (LAT), a transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets.
Keine Kreuzreaktivität Human
Reinigung Purified from hybridoma culture supernatant by protein-A affinity chromatography.
Reinheit > 95 % (by SDS-PAGE)
Plasmids, Primers & others Plasmide, Primers & weitere LAT products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung LAT (LAT Antibody Abstract)
Hintergrund LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
Pathways T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Do not freeze.
Lagerung 4 °C
Informationen zur Lagerung Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Bilder des Herstellers
Immunocytochemistry (ICC) image for anti-Linker For Activation of T Cells (LAT) antibody (ABIN94420) Distribution of LAT and NTAL in separate clusters on mast cell plasma membrane sheets...
Immunocytochemistry (ICC) image for anti-Linker For Activation of T Cells (LAT) antibody (ABIN94420) Distribution of LAT and NTAL in separate clusters on mast cell plasma membrane sheets...
Allgemeine Veröffentlichungen Yamasaki, Ishikawa, Sakuma, Kanagawa, Cheng, Malissen, Saito: "LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival." in: Molecular and cellular biology, Vol. 27, Issue 12, pp. 4406-15, 2007 (PubMed).

Produkt verwendet in: Lebduska, Korb, T?mová, Heneberg, Dráber: "Topography of signaling molecules as detected by electron microscopy on plasma membrane sheets isolated from non-adherent mast cells." in: Journal of immunological methods, Vol. 328, Issue 1-2, pp. 139-51, 2007 (PubMed).

Heneberg, Lebduska, Dráberová, Korb, Dráber: "Topography of plasma membrane microdomains and its consequences for mast cell signaling." in: European journal of immunology, Vol. 36, Issue 10, pp. 2795-806, 2006 (PubMed).

Volná, Lebduska, Dráberová, Símová, Heneberg, Boubelík, Bugajev, Malissen, Wilson, Horejsí, Malissen, Dráber: "Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL." in: The Journal of experimental medicine, Vol. 200, Issue 8, pp. 1001-13, 2004 (PubMed).

Tolar, T?mová, Dráber: "New monoclonal antibodies recognizing the adaptor protein LAT." in: Folia biologica, Vol. 47, Issue 6, pp. 215-7, 2001 (PubMed).

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