SEMA7A Antikörper

Produktnummer ABIN93945

Produktdetails anti-SEMA7A Antikörper

Target: SEMA7A (Semaphorin 7A, GPI Membrane Anchor (John Milton Hagen Blood Group) (SEMA7A))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SEMA7A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS)

Spezifität: The antibody MEM-150 reacts with CD108 (JMH blood group antigen), a 80 kDa GPI-anchored extracellular glycoprotein expressed on various cell types including erythrocytes, lymphoblasts, at low levels it is present on circulating lymphocytes.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: HPB-ALL human T cell line

Klon: MEM-150

Isotyp: IgM

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 4 μg/mL.
Western blotting: Non-reducing conditions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-SEMA7A Antikörper (ABIN93945)

Angelisová, Drbal, Cerný, Hilgert, Horejsí: "Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules." in: Immunobiology, Vol. 200, Issue 2, pp. 234-45, (1999) (PubMed).

Mudad, Rao, Angelisova, Horejsi, Telen: "Evidence that CDw108 membrane protein bears the JMH blood group antigen." in: Transfusion, Vol. 35, Issue 7, pp. 566-70, (1995) (PubMed).

Details zu SEMA7A

Target: SEMA7A (Semaphorin 7A, GPI Membrane Anchor (John Milton Hagen Blood Group) (SEMA7A))

Andere Bezeichnung: CD108 (SEMA7A Produkte)

Synonyme: 2900057C09Rik antikoerper, CDw108 antikoerper, H-Sema-L antikoerper, M-Sema-L antikoerper, Semal antikoerper, CD108 antikoerper, H-SEMA-K1 antikoerper, JMH antikoerper, SEMAK1 antikoerper, SEMAL antikoerper, sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A antikoerper, semaphorin 7A (John Milton Hagen blood group) antikoerper, Sema7a antikoerper, SEMA7A antikoerper

Hintergrund: Semaphorin 7A (John Milton Hagen blood group),CD108 (Sema7A) is a GPI-anchored semaphorin family member, which enhances central and peripheral axonal growth and is required for proper axon track formation during ebryogenesis. CD108 also regulates osteoclast differentiation and pre-osteoblastic cell migration, and in immune system affects cell proliferation, chemotaxis and cytokine release. On erythrocytes CD108 defines the JMH (John-Milton-Hagen) human blood group. CD108 signalizes through its receptors –, plexin C1 and beta1 integrins.,Semaphorin 7a, JMH blood group antigen, SEMAL, SEMAK1

Gen-ID: 8482

UniProt: O75326

Pathways: Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Cell Size