CBFA2T2 Antikörper

Produktnummer ABIN930909

Produktdetails anti-CBFA2T2 Antikörper

Target: CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CBFA2T2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Dot Blot (DB), Flow Cytometry (FACS)

Kreuzreaktivität: Human

Kreuzreaktivität (Details): Other species not studied.

Aufreinigung: Protein G affinity chromatography

Immunogen: CBFA2 T2 antibody was raised in mouse using recombinant Core-Binding Factor,Alpha Subunit 2

Klon: CBF5I134

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 0.2-2 µg/mL, FC: 0.5-2 µg/sample, ICC: 2-100 µg/mL
Optimal conditions should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: Lot specific

Buffer: CBFA2 T2 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3).

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.

Details zu CBFA2T2

Target: CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

Andere Bezeichnung: CBFA2T2 (CBFA2T2 Produkte)

Synonyme: MTGR1 antikoerper, A430091M07 antikoerper, C330013D05Rik antikoerper, Cbfa2t2h antikoerper, EHT antikoerper, ZMYND3 antikoerper, p85 antikoerper, XETOR antikoerper, cbfa2t2-a antikoerper, CBFA2/RUNX1 translocation partner 2 antikoerper, core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) antikoerper, CBFA2/RUNX1 translocation partner 2 L homeolog antikoerper, Cbfa2t2 antikoerper, CBFA2T2 antikoerper, cbfa2t2.L antikoerper

Hintergrund: In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. Synonyms: Monoclonal CBFA2T2 antibody, Anti-CBFA2T2 antibody, Core-binding factor runt domain alpha subunit 2 antibody, MTGR1 antibody, EHT antibody, ZMYND3 antibody.