TDP1 Antikörper (Middle Region)

Produktnummer ABIN928939

Produktdetails anti-TDP1 Antikörper

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TDP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Maus

Aufreinigung: Purified

Immunogen: Tdp1 antibody was raised in rabbit using the middle region of Tdp1 as the immunogen

Anwendungsinformationen

Applikationshinweise: Optimal conditions should be determined by the investigator.

Kommentare:

Tdp1 Blocking Peptide, catalog no. 33R-2766, is also available for use as a blocking control in assays to test for specificity of this Tdp1 antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu TDP1

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Andere Bezeichnung: Tdp1 (TDP1 Produkte)

Synonyme: 2810481F14Rik antikoerper, 4921509N21Rik antikoerper, AI838772 antikoerper, AW493413 antikoerper, E430034L06Rik antikoerper, MLZ-501 antikoerper, SCAN1 antikoerper, tdp1 antikoerper, MGC83708 antikoerper, TDP1 antikoerper, F8M21.60 antikoerper, F8M21_60 antikoerper, tyrosyl-DNA phosphodiesterase 1 antikoerper, tyrosyl-DNA phosphodiesterase 1 antikoerper, tyrosyl-DNA Phosphodiesterase (Tdp1) antikoerper, tyrosyl-DNA phosphodiesterase 1 L homeolog antikoerper, tyrosyl-DNA phosphodiesterase-like protein antikoerper, TDP1 antikoerper, Tc00.1047053511191.10 antikoerper, Tdp1 antikoerper, tdp1.L antikoerper, tdp1 antikoerper, PTRG_11198 antikoerper, MCYG_02121 antikoerper, MGYG_03035 antikoerper

Hintergrund: Tdp1 is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. It catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. It hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. It acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. It has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. It has no exonuclease activity towards DNA or RNA with a 3'phosphate. Synonyms: Polyclonal Tdp1 antibody, Anti-Tdp1 antibody, tyrosyl-DNA phosphodiesterase 1 antibody, 2810481F14Rik antibody, 4921509N21Rik antibody, AI838772 antibody, AW493413 antibody, E430034L06Rik antibody, SCAN1 antibody.