PSMD10 Antikörper (N-Term)

Produktnummer ABIN928857

Produktdetails anti-PSMD10 Antikörper

Target: PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSMD10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Maus

Aufreinigung: Purified

Immunogen: Psmd10 antibody was raised in rabbit using the N terminal of Psmd10 as the immunogen

Anwendungsinformationen

Applikationshinweise: Optimal conditions should be determined by the investigator.

Kommentare:

Psmd10 Blocking Peptide, catalog no. 33R-4354, is also available for use as a blocking control in assays to test for specificity of this Psmd10 antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu PSMD10

Target: PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))

Andere Bezeichnung: Psmd10 (PSMD10 Produkte)

Synonyme: gankyrin antikoerper, zgc:109707 antikoerper, dJ889N15.2 antikoerper, p28 antikoerper, p28(GANK) antikoerper, AW554874 antikoerper, p28Gank antikoerper, proteasome 26S subunit, non-ATPase 10 antikoerper, proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 antikoerper, psmd10 antikoerper, PSMD10 antikoerper, Psmd10 antikoerper

Hintergrund: Psmd10 acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly,Psmd10 is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module By similarity.Psmd10 acts as an oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression of this gene is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Psmd10 regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Synonyms: Polyclonal Psmd10 antibody, Anti-Psmd10 antibody, proteasome, prosome, macropain 26S subunit, non-ATPase, 10 antibody, AW554874 antibody.

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Ubiquitin Proteasome Pathway